✅ Active Ingredient Overview Table:

🔬 Active Ingredient (Generic Name):	Isotretinoin
💊 Indication:	Severe Recalcitrant Nodular Acne, Off-Label: Rosacea, Hidradenitis Suppurativa
🇺🇸 US Brand:	Accutane, Claravis
🏭 Manufacturer:	Healing Pharma (Founded: 2010)
📦 Packaging:	10 Capsules per Strip
🧪 Strength:	30 mg
🚚 Delivery Time:	6–15 days

🌿 What is Isotretinoin 30 mg (Accufine)?

Acne is not only a physical condition but also a significant psychosocial burden. Severe, treatment-resistant nodular acne can lead to scarring, emotional distress, and reduced self-esteem. Accufine 30 mg addresses these challenges by delivering a high daily dose of isotretinoin, a retinoid that targets all major pathogenic factors of acne: it shrinks sebaceous glands, reduces sebum production, normalizes follicular keratinization, and exerts potent anti-inflammatory effects.

By achieving higher systemic exposure early in treatment, the 30 mg regimen accelerates lesion resolution and promotes sustained remission. Rapid sebum reduction often becomes apparent within 2–4 weeks, improving dermatologic and psychological outcomes for patients living with severe, recalcitrant acne. Off-label, Accufine 30 mg is also leveraged in refractory rosacea and hidradenitis suppurativa to harness its anti-inflammatory and keratinization-normalizing properties.

🧬 Pharmacology & Mechanism of Action

Attribute	Detail
Chemical Formula	C20H28O2
Molecular Weight	300.44 g/mol
Bioavailability	~25% (increases with high-fat meals)
Metabolism	Hepatic (CYP2C8, CYP2C9)
Half-Life	10–20 hours

Isotretinoin modulates gene expression via retinoic acid receptors, leading to reduced sebocyte proliferation, normalized keratinization, and anti-inflammatory effects.

💡 Indications & Dosing

Condition	Dose & Administration
Severe Nodular Acne	30 mg once daily; titrate by body weight to achieve cumulative 120–150 mg/kg over ~8–10 weeks
Off-Label: Rosacea & Hidradenitis Suppurativa	20 mg once daily for 3–6 months, adjust per response

Take Accufine with a meal to enhance absorption. 30 mg dosing accelerates reaching therapeutic cumulative levels. Monitor weight to calculate cumulative dose and adjust duration accordingly.

⚠️ Warnings & Side Effects

Common:

Cheilitis, xerosis, skin fragility
Photosensitivity, muscle aches

Serious:

Teratogenicity; adherence to pregnancy prevention program mandatory
Elevated triglycerides, hepatotoxicity
Mood disturbances, rarely suicidal ideation

Female patients of childbearing potential must use two contraception methods and have monthly pregnancy tests. Perform monthly LFTs, lipid panels, and mood assessments.

🏥 Storage Instructions

Store Accufine 20 mg at 20–25°C in original blister pack. Protect from moisture and light. Keep out of reach of children.

🌐 Availability & Purchasing

USA: Prescription-only (Accutane); isotretinoin under strict REMS.
UK & EU: iPLEDGE equivalents require monitoring.
Australia: Schedule 4 medicine; pregnancy prevention required.

Importing from India may reduce costs; ensure compliance with local guidelines and pregnancy prevention protocols.

🔗 Related Dermatologic Therapies

Accufine 10 mg – moderate-dose isotretinoin.

🎥 Educational Video on High-Dose Isotretinoin Therapy

👩‍⚕️ Expert Insight: Dr. Anita Kapoor, Dermatologist

“High-dose isotretinoin like Accufine 20 mg can shorten treatment courses, but requires rigorous monitoring for lipid, hepatic, and mood changes to maintain safety.”