✅ Active Ingredient Overview Table:

🔬 Active Ingredient (Generic Name):	Isotretinoin
💊 Indication:	Severe Recalcitrant Nodular Acne, Off-Label: Rosacea, Hidradenitis Suppurativa
🇺🇸 US Brand:	Accutane, Claravis
🏭 Manufacturer:	Healing Pharma (Founded: 2010)
📦 Packaging:	10 Capsules per Strip
🧪 Strength:	5 mg
🚚 Delivery Time:	6–15 days

🌿 What is Isotretinoin 5 mg (Accufine)?

Accufine delivers 5 mg of isotretinoin, a vitamin A derivative that dramatically reduces sebaceous gland size and sebum production, normalizes keratinization, and exhibits anti-inflammatory properties. This mechanism addresses the root causes of severe acne, offering long-term remission in many patients.

Early in therapy, patients may see transient flare-ups before marked improvement in lesion count and skin texture. Standard courses range from 16–24 weeks, with cumulative dosing predicting relapse rates—higher total doses correlate with sustained remission. Off-label, low-dose regimens of 5 mg daily are successfully used for milder inflammatory conditions like rosacea and hidradenitis suppurativa, balancing efficacy and tolerability.

🧬 Pharmacology & Mechanism of Action

Attribute	Detail
Chemical Formula	C20H28O2
Molecular Weight	300.44 g/mol
Bioavailability	~25% (increases with food)
Metabolism	Hepatic (CYP2C8, CYP2C9)
Half-Life	10–20 hours

Isotretinoin normalizes follicular keratinocyte growth, decreases P. acnes colonization, and reduces sebum excretion, leading to lesion clearance.

💡 Indications & Dosing

Condition	Dose & Administration
Severe Nodular Acne	0.5 mg/kg/day in two divided doses; total cumulative dose 120–150 mg/kg over 16–24 weeks
Milder Inflammatory Conditions (Off-Label)	5 mg once daily or 5 mg three times weekly for 3–6 months

Take Accufine with a meal to enhance absorption. Monitor lipid profile and liver enzymes monthly due to dose-dependent effects.

⚠️ Warnings & Side Effects

Common:

Dry skin, cheilitis, xerosis
Photosensitivity, myalgia

Serious:

Teratogenicity (strict pregnancy prevention program)
Elevated triglycerides, hepatotoxicity
Mood changes (depression, rare suicidality)

Female patients of childbearing potential must adhere to two forms of contraception and monthly pregnancy tests. Monitor lipids, LFTs, and mental health regularly.

🏥 Storage Instructions

Store Accufine 5 mg at 20–25°C in original blister pack. Protect from light and moisture. Keep out of reach of children.

🌐 Availability & Purchasing

USA: Prescription-only (Accutane); generic isotretinoin available under strict REMS guidelines.
UK & EU: Prescription required; iPLEDGE equivalent programs mandate monitoring.
Australia: Prescription via S8 schedule; pregnancy prevention required.

Importing from India may lower costs, but ensure compliance with local pregnancy prevention regulations.

🔗 Related Dermatologic Therapies

Adapalene Gel 0.1% – topical retinoid.
Azelaic Acid 20% gel – antimicrobial and comedolytic.
Tazarotene 0.1% Cream – potent topical retinal.

🎥 Educational Video on Isotretinoin Therapy

👩‍⚕️ Expert Insight: Dr. Anita Kapoor, Dermatologist

“Low-dose isotretinoin regimens like Accufine 5 mg can maintain efficacy with fewer side effects, improving patient adherence and expanding utility beyond severe acne.”