✅ Active Ingredient Overview Table:

🔬 Active Ingredients:	Adapalene 0.1% w/w, Clindamycin Phosphate 1% w/w
💊 Indication:	Acne Vulgaris (Comedonal & Inflammatory Lesions)
🇺🇸 US Brand Equivalent:	Epiduo (Galderma)
🏭 Manufacturer:	Systopic Laboratories Pvt Ltd (Founded: 2002)
📦 Packaging:	15 g Tube
🚚 Delivery Time:	6–15 days

🌿 What is Acnesol A Nano Gel?

Acnesol A Nano Gel combines 0.1% adapalene, a potent topical retinoid that normalizes follicular keratinization, with 1% clindamycin, an antibiotic targeting Propionibacterium acnes. The nano-emulsion base enhances skin penetration, delivering active ingredients deep into hair follicles for rapid reduction of both non-inflammatory comedones and inflammatory papules.

Patients often face persistent acne due to follicular blockages and bacterial colonization leading to inflammation and potential scarring. Acnesol A Nano Gel addresses these root causes synergistically: adapalene reduces microcomedone formation and inflammation, while clindamycin eradicates pathogenic bacteria, halting lesion progression.

Clinical studies demonstrate up to a 75% reduction in total lesion count at 12 weeks with combination therapy, outperforming monotherapy. The nano formulation improves tolerability by reducing irritant effects of adapalene and optimizing antibiotic delivery.

🧬 Pharmacology & Mechanism of Action

Attribute	Detail
Adapalene	Binds RAR-β and RAR-γ → normalizes keratinocyte differentiation; anti-inflammatory
Clindamycin	50S ribosomal subunit binding → inhibits bacterial protein synthesis; bacteriostatic
Nano-Emulsion Base	<200 nm particle size → enhanced follicular penetration; reduced irritation

💡 Indications & Application

Condition	Application
Acne Vulgaris	• Cleanse and dry skin.
• Apply a pea-sized amount once daily in the evening.
• Continue for at least 12 weeks.

Avoid contact with eyes, lips, and mucous membranes. Use non-comedogenic moisturizer and sunscreen.

⚠️ Warnings & Side Effects

Common:

Erythema, dry skin, peeling
Burning or stinging sensation

Serious (rare):

Allergic contact dermatitis
Clostridioides difficile–associated diarrhea (with prolonged use of clindamycin)

Advise patients to apply moisturizer and avoid sun exposure. If severe irritation occurs, reduce frequency or discontinue.

🏥 Storage Instructions

Store Acnesol A Nano Gel at 20–25°C in original tube. Protect from light and moisture. Keep out of reach of children.

🌐 Availability & Purchasing

USA: Prescription-only (Epiduo); generic combination products available.
UK & EU: Prescription required; adapalene-clindamycin combos accessible.
Australia: Prescription and TGA approval necessary.

Systopic’s nano gel formulation offers an affordable alternative. Ensure adherence to local prescribing guidelines.

🔗 Related Combination Acne Therapies

Epiduo Gel – adapalene 0.1%/benzoyl peroxide 2.5%.

🎥 Educational Video on Combination Acne Therapy

👩‍⚕️ Expert Insight: Dr. Ritu Anand, Dermatologist

“By combining adapalene and clindamycin in a nano-emulsion, Acnesol A Nano Gel optimally delivers active ingredients to pilosebaceous units, improving outcomes while minimizing irritation—a true advancement in topical acne therapy.”