💉 Hormone Replacement Therapy • Estrogen • Women’s Health

Estraval Depot 10mg — Complete Guide to Estradiol Valerate Injection

📋 Actiza Pharma • HRT • Menopause • ART • 6 min read

🧫 Watch: Understanding how long-acting estrogen injections function in menopause and fertility care.

📋 Product Overview

💊 Active Ingredient	Estradiol Valerate 10mg
🏭 Manufacturer	Actiza Pharmaceutical Pvt. Ltd., India
💉 Dosage Form	Injectable Solution (Depot Form)
📦 Packaging	10 x 1ml ampoules per box
🩺 Indication	HRT, Estrogen Deficiency, ART
🇺🇸 US Brand Equivalent	Delestrogen
⏱️ Delivery Time	6 to 15 business days

🧬 Introduction — What Is Estraval Depot 10mg?

Estraval Depot 10mg, manufactured by Actiza Pharmaceutical Pvt. Ltd., is a long-acting injectable estrogen preparation that contains Estradiol Valerate, a synthetic estrogen ester. This medication is used for Hormone Replacement Therapy (HRT) in women experiencing menopausal symptoms or estrogen deficiency, and in Assisted Reproductive Technologies (ART) to prepare the endometrium.

Administered intramuscularly, this depot injection ensures slow and sustained release, making it convenient for patients requiring long-term hormonal therapy.

🩺

HRT

Menopause symptom relief

🧬

ART / IVF

Endometrial preparation

💉

Long-Acting

Sustained release depot

💡 Key Advantage: This injectable solution is a viable alternative to oral estrogens for those who experience GI issues or prefer less frequent dosing schedules.

🔬 Mechanism of Action

⚗️ Component	🔍 Pharmacodynamics
Estradiol Valerate 10mg	Slowly hydrolyzed to estradiol, binds to estrogen receptors, regulates target tissue activity

🌡️ Reduces vasomotor symptoms of menopause
🧬 Supports endometrial growth for embryo transfer
🩺 Assists in the management of hypogonadism or ovarian failure

💡 Dosing & Administration

📋 Indication	💉 Typical Dosage
Hormone Replacement Therapy	10–20mg IM every 4 weeks
Estrogen Deficiency (Hypogonadism)	10mg IM every 2–4 weeks
ART / IVF Endometrial Preparation	10mg IM as directed in protocol

📌 Important: Administer via deep intramuscular injection only. Dosage varies based on indication and individual patient needs.

⚠️ Side Effects & Contraindications

Common Reactions

Breast tenderness
Headache
Nausea
Injection site pain
Water retention
Mood swings

Serious Risks

Deep vein thrombosis
Stroke
Endometrial cancer
Liver dysfunction
Gallbladder disease
Estrogen-dependent neoplasia

Contraindications:

🚫 Pregnancy
🚫 History of thromboembolic disease
🚫 Estrogen-sensitive cancers
🚫 Undiagnosed abnormal genital bleeding

🧊 Storage Instructions

🌡️ Store below 25°C (77°F)
❄️ Do not freeze
🛡️ Protect from light
🚸 Keep out of reach of children
📅 Check expiration date before use

🌍 Availability & Import Rules

🌎 Region	🚚 Import Eligibility	📋 Prescription Required
🇺🇸 USA	Permitted under FDA personal import policy	✅ Yes
🇬🇧 UK	Allowed under MHRA guidelines	✅ Yes
🇦🇺 Australia	Personal import scheme accepted by TGA	✅ Yes

📦 Delivery estimate: 6–15 working days via trusted Indian exporters.

🔗 Related Hormonal Medications

💊 Product	🏭 Manufacturer	📖 Description
Progynova 2mg	Zydus Healthcare	Oral estrogen therapy for menopause and IVF
Duphaston 10mg	Abbott India	Progestogen used in endometrial protection and HRT
Susten 200mg	Sun Pharma	Natural progesterone for luteal phase and pregnancy support
Cabgolin 0.5mg	Sun Pharma	For prolactin-related menstrual disorders
Deviry 10mg	Medley Pharma	Regulates menstrual cycle, supports HRT

🩺 Expert Review — Dr. Rachita Mehra, MD (Reproductive Endocrinology)

“Estraval Depot 10mg is an effective injectable estrogen that provides a steady hormone level over weeks. It is ideal for women preferring less frequent administration or those in advanced fertility treatment protocols. The depot formulation ensures consistent hormone levels, which is particularly beneficial in ART cycles where endometrial preparation is critical.”

— Dr. Rachita Mehra, MD (Reproductive Endocrinology)

🗓️ Reviewed: June 30, 2026

📚 References & External Resources

⚠️ Medical Disclaimer

This content is for informational and educational purposes only. Estraval Depot 10mg (Estradiol Valerate) is a prescription medication that should only be used under the supervision of a qualified healthcare professional. Always consult your healthcare provider before beginning, changing, or discontinuing any hormone replacement therapy.