📋 Product Overview Table

🌐 Specification	🧾 Details
💊 Product Name	Evermil 10 mg Tablets
🧬 Active Ingredient	Everolimus (mTOR inhibitor)
🏭 Manufacturer	Glenmark Pharmaceuticals Ltd (India)
💡 Indication	Organ transplant rejection prophylaxis; various advanced cancers (e.g., renal, breast, NETs)
🇺🇸 US Brand	Afinitor® / Zortress®
📦 Packaging	10 tablets per strip
🌍 Country of Origin	India
⏱️ Delivery Time	6–15 business days

🧬 Introduction – What is Evermil 10 mg?

Evermil 10 mg is an oral mTOR inhibitor (everolimus) used for immune suppression post-transplant and as a targeted therapy in advanced cancers. Manufactured by Glenmark, Evermil offers both anti-rejection and anti-proliferative effects by blocking mTOR—a key cell growth pathway (drugssquare.com, en.wikipedia.org, en.wikipedia.org).

🎥 Educational Video Overview

📺 “Understanding Everolimus: How It Works in Transplant & Cancer Care”
🎬 Video Placeholder – Explains mechanism, dosing, side effects, and monitoring.

💬 Reviewed by: Dr. Arjun Mehta, MD (Transplant & Oncology specialist)

🔬 Mechanism of Action

Evermil selectively binds FKBP-12 and inhibits mTORC1, leading to:

Suppression of T-cell proliferation—reducing transplant rejection (en.wikipedia.org)
Inhibition of tumor cell growth in breast, kidney, neuroendocrine, and other cancers (biosynpharmaceuticals.com)

💊 Indications & Dosage Guidelines

🩺 Condition	🔢 Dose
Post‑transplant (kidney, liver)	Typically 0.75 mg/m² orally twice daily
Advanced kidney cancer	10 mg once daily
HR+/HER2– breast cancer (with exemestane)	10 mg once daily
Pancreatic/lung NETs	10 mg once daily

Dosage varies—clinicians adjust based on response and lab values (reference.medscape.com, apothecare.in, en.wikipedia.org, biosynpharmaceuticals.com).

⚠️ Side Effects & Precautions

Common (≥10%)

Stomatitis, rash, diarrhea, fatigue, edema, anemia (drugs.com)
Increased risk of infections, hyperglycemia, hyperlipidemia (reference.medscape.com)

Serious

Pneumonitis, nephrotoxicity, thrombocytopenia, delayed wound healing (en.wikipedia.org)
Avoid live vaccines and grapefruit—can elevate levels dangerously (drugs.com)

Regular labs are essential: CBC, renal, liver, blood sugar, lipids.

🧃 Storage & Handling

Store 15–30 °C (59–86 °F) (mayoclinic.org, my.clevelandclinic.org)
Keep in blister, away from moisture and light

🔗 Indian Alternatives

💊 Medicine	🏭 Manufacturer	📝 Description
Afinitor 10 mg	Novartis	Name-brand everolimus for oncology & transplant dosing
Zortress 1 mg	Novartis	Everolimus formulation for transplant rejection
Votubia 5 mg	Novartis	Indicated for TSC-associated SEGA in children/adolescents
Evervéd 10 mg	Sun Pharma	Generic everolimus for cancer and transplant indications
Evorol 10 mg	Natco Pharma	Generic option used in multiple oncology and transplant settings

📚 References & External Resources

🩺 Expert Commentary – Dr. Arjun Mehta, MD

“Everolimus acts on the mTOR pathway, balancing immune suppression after transplant and targeting cancer cell proliferation. Close monitoring is key to maximize benefit and minimize adverse effects.”

⚠️ Disclaimer

This article is informational only. Evermil 10 mg should be used under specialist supervision. Discuss benefits, risks, and monitoring with your physician before starting.