🏷️ Parameter	🔍 Details
🧬 Active Ingredients	Tenofovir DF 300mg + Emtricitabine 200mg + Efavirenz 600mg
💊 Indication	HIV-1 Infection (First-line ART for adults/adolescents ≥40kg)
🇺🇸 US Brand	Atripla®
🏭 Manufacturer	Cipla Ltd.
📦 Packaging	30 tablets in 1 HDPE bottle
💪 Strength	300mg/200mg/600mg per tablet
🚚 Delivery Time	7–14 days (Worldwide)

🧬 Introduction to Viraday

Viraday by Cipla is a complete once-daily HIV regimen combining:

🦴 Tenofovir DF 300mg (NRTI: nucleotide reverse transcriptase inhibitor)
🧬 Emtricitabine 200mg (NRTI: cytidine analog with dual HIV/HBV activity)
🧠 Efavirenz 600mg (NNRTI: CNS-penetrating reverse transcriptase inhibitor)

Approved for HIV-1 treatment in patients ≥40kg, this 30-tablet bottle offers:

✅ Simplified dosing (1 tablet at bedtime)
✅ High barrier to resistance
✅ WHO-preferred first-line regimen
⚠️ Neuropsychiatric side effects (50% incidence)
❗ Black-box warning for severe depression/suicidality

Cipla’s generic version provides affordable access to this gold-standard regimen.

💊 Dosage & Indications

💉 Indication	🧪 Dosage	⏱️ Frequency	💡 Notes
Adults ≥40kg	1 tablet	Once daily	At bedtime on empty stomach
Adolescents 35-40kg	Not recommended	–	Use separate formulations
Renal Impairment	Avoid if CrCl <50 mL/min	Contraindicated	Tenofovir accumulation
Hepatic Impairment	Avoid in severe cirrhosis	–	Efavirenz metabolism reduced

⚠️ Side Effects, Storage & Warnings

❗ Common Side Effects:
- Dizziness (52%)
- Vivid dreams (48%)
- Rash (30%)
🚫 Serious Effects:
- Severe depression/suicidal ideation
- Fanconi syndrome (Tenofovir-induced kidney damage)
- Stevens-Johnson syndrome
❄️ Storage: 15–30°C; keep bottle tightly closed (desiccant included).
⚠️ Critical Warnings:
- Contraindicated in psychiatric disorders or seizure history
- Baseline & annual: Bone mineral density scans
- Monthly renal monitoring (CrCl, urine glucose/protein)

🌍 Global Availability & Shipping

🌎 Region	📦 Shipping	💵 Price (30-tablet bottle)	📜 Prescription
🇺🇸 USA	✅ Yes	$75–$120	Required
🇬🇧 UK	✅ Yes	£60–£95	Required
🇦🇺 Australia	✅ Yes	AUD 100–150	Required

🔗 Related Indian Alternatives (Different in Same Category)

💊 Product Name	🏭 Manufacturer	🔗 Internal Link
Dolutranz (Dolutegravir/Tenofovir)	Mylan	dolutranz
Tenof-EM (Tenofovir/Emtricitabine)	Hetero	tenof-em
Efavir (Efavirenz)	Cipla	efavir
Tavin-EM (Tenofovir/Emtricitabine)	Cipla	tavin-em
Lopimune (Lopinavir/Ritonavir)	Cipla	lopimune
Covihope-D (Dolutegravir/Ritonavir)	Hetero	covihope-d

📚 External Medical References

🩺 Expert Commentary

Dr. Karan Sharma, HIV Specialist:
“Viraday’s once-daily convenience comes with significant CNS effects. I initiate it on Fridays so patients can adjust over weekends. For those with depression history, [dolutranz] (Dolutegravir-based) is safer. Cipla’s bottle has light-blocking properties to protect Efavirenz from photodegradation.”

📌 Disclaimer

This information is not medical advice. Use under physician supervision. Cipla’s Viraday carries black-box warnings for severe psychiatric adverse reactions.

💡 Clinical Protocol:

Neuropsychiatric Management:

Symptom Action

Mild dizziness Take 2 hours before bedtime

Vivid dreams Reassurance + temporary sleep aid

Suicidal thoughts IMMEDIATE DISCONTINUATION
Renal/Bone Monitoring Schedule:

Test Frequency Action Threshold

Creatinine Clearance Quarterly <50 mL/min

Urine Protein Semi-annual >500 mg/24h

DEXA Scan Baseline, Biannual T-score <-2.0
Bottle Specifications:
- Amber HDPE bottle with UV protection
- “CIP-VD” embossed on tablets
- Silica gel canister (do not eat)
Drug Interactions:
- ⚠️ Rifampicin: Reduces Efavirenz levels (avoid)
- ⚠️ PPIs: Reduce Atazanavir concentrations
- ⚠️ Warfarin: Requires INR monitoring