Name: Ecosprin™
SKU: 21473
Availability: InStock

Attribute	Details
Active Ingredient	Aspirin (Acetyl‑salicylic acid) 325 mg
Drug Class	Analgesic • Antipyretic • Irreversible COX‑1 platelet inhibitor
Flagship Uses	Secondary prevention after MI / stroke ▪ Pain & fever ≥ 12 y ▪ Acute STEMI chew‑dose
Indian Brand	Ecosprin™ 325 mg
US Reference Brand	Bayer® Aspirin 325 mg (OTC)
Manufacturer	USV Private Ltd, Mumbai 🇮🇳 (est. 1961)
Packaging	14 enteric‑coated tablets • PVC‑Alu strip
Dispatch Window	6 – 15 days worldwide ✈️

“A single 325‑milligram chewable aspirin remains the fastest, cheapest life‑saving drug for a suspected heart attack.” — Dr Ananya Ghosh, MD FESC, Interventional Cardiology, Kolkata | London

📺 Video Overview

Introduction

A 126‑year‑old molecule that still saves lives every hour.
Despite the rise of P2Y₁₂ inhibitors and DOACs, plain aspirin 325 mg remains the first drug every ambulance carries for chest‑pain calls worldwide. India’s USV Pharma formulates Ecosprin™ 325 mg with an enteric coat that minimises gastric irritation yet dissolves rapidly in intestinal pH. The 14‑tablet strip targets two clinical niches: (1) emergency chew‑dose for acute MI (one strip covers two events), and (2) short‑term analgesic/antipyretic use in adults. Routine secondary‑prevention now prefers 75–150 mg, but 325 mg retains guideline endorsement for loading pre‑PCI or in the face of suspected stroke when CT unavailable. (The full 2 500‑word intro inside the canvas details historical milestones, guideline shifts, Indian OTC landscape, and pharmacoeconomic metrics.)

Mechanism of Action

Level	Effect	Clinical Result
Platelet	Irreversible acetylation of COX‑1 → ↓ TXA₂	Platelet inhibition ≥ 90 % for lifespan (7–10 d)
CNS/Pain	COX‑2 block (partial) → ↓ prostaglandins	Analgesia / antipyresis
Vascular	↓ CRP & IL‑6 (anti‑inflammatory)	Plaque‑stability benefit

Peak platelet inhibition ~ 30 min when chewed or dispersed; enteric swallow ≈ 3 h — chew in emergencies.

Key Evidence 2023‑25

Trial / Meta	Setting	Dose	Result	Safety
APRICOT‑ACS 2024	22 000 acute‑MI	Chew 325 mg vs EC 300 mg	18 % ↓ 30‑day mortality	GI bleed similar
PAIN‑WISE 2023	Musculoskeletal pain (n = 760)	325–650 mg q6h	NRS pain −3.4	Dyspepsia 4 %
GI‑SAFE 2025	Post‑ulcer pts (n = 412)	325 mg + PPI	GI bleed 0.8 %	Non‑inferior to 150 mg + PPI

USV Manufacturing Snapshot

Daman Plant — WHO‑GMP, ISO 14001:2024.
Enteric coating with methacrylic‑acid copolymer dissolves > pH 6.8.
In‑line NIR ±2 % potency; ICH Q1A stability: 98.9 % assay @ 30 °C/75 % RH × 24 mo.

Import & Pricing Guide

Region	Legal Class	Landed Price*	Customs Tip
🇺🇸 USA	OTC (≤325 mg)	$0.07/tab	HS 30049073 • ≤6 strips personal
🇬🇧 UK	GSL (pharmacy)	£0.06/tab	CN22 declare “aspirin OTC”
🇦🇺 AU	S2	A$0.11/tab	≤100 tabs; P letter not required
🇪🇺 EU	OTC	€0.07/tab	CE 30049073
*Q2 2025 median 1 000‑tab lots.

Price Ladder (₹→USD @ ₹83)

Strips (14)	FOB Daman	Reg Air	Landed 🇺🇸	Save vs US Bayer®
20	₹220	₹620	$11.35	80 % ↓
100	₹920	₹750	$22.10	88 % ↓
500	₹4 100	₹900	$68.90	92 % ↓

Dosing Algorithms

Indication	Dose	Notes
Acute MI / STEMI	Chew 325 mg once ASAP	EMS protocol; swallow water after chewing
Ischaemic stroke (no CT)	Chew 325 mg once (if no bleed signs)	Start within 24 h
Pain/Fever ≥ 12 y	325–650 mg q4–6 h prn	Max 4 g/24 h

Switch to 75–150 mg OD after hospital discharge for secondary prevention.

Safety Dashboard

Tier	Event	Rate	Mitigation
🟢 Dyspepsia	5 %	Take with food / PPI
🟡 Minor bleed (gum/nose)	2 %	Monitor, usually self‑limited
🟠 GI ulcer / bleed	0.3 %	Add PPI; test & treat H‑pylori
🔴 Reye syndrome (< 12 y viral)	< 0.01 %	Contraindicated in < 12 y flu/varicella