Name: Acnedap Gel
SKU: 23336
Availability: InStock

✅ Active Ingredient Overview Table:

🔬 Active Ingredient (Generic Name):	Dapsone 5% w/w
💊 Indication:	Acne Vulgaris (Inflammatory Lesions & Papulopustular Acne)
🇺🇸 US Brand Equivalent:	Aczone (Dapsone 5% Gel)
🏭 Manufacturer:	Cipla Limited (Founded: 1935)
📦 Packaging:	15 g Tube
🧪 Strength:	5% w/w
🚚 Delivery Time:	6–15 days

🌿 What is Acnedap Gel 5%?

Acnedap Gel contains Dapsone 5%, a sulfone antibiotic with anti-inflammatory properties, formulated for topical treatment of acne vulgaris. It is specifically indicated for inflammatory papules and pustules. By reducing neutrophil-mediated inflammation and exhibiting antibacterial activity against Cutibacterium acnes, Dapsone helps decrease lesion counts and erythema. Acnedap offers twice-daily application with a non-greasy gel base, suitable for most skin types, including oily and combination skin.

🧬 Pharmacology & Mechanism of Action

Attribute	Detail
Chemical Formula	C12H12N2O2S
Molecular Weight	248.30 g/mol
Mechanism	• Antibacterial: Inhibits dihydropteroate synthase → disrupts folate synthesis in bacteria (e.g., C. acnes) • Anti-inflammatory: Reduces neutrophil chemotaxis & myeloperoxidase-derived oxidants → decreases erythema and inflammation
Vehicle	Aqueous gel: Enhances penetration, non-comedogenic, and minimizes skin irritation

💡 Indications & Application Guidelines

Condition	Application Regimen
Inflammatory Acne Vulgaris	• Cleanse affected area with mild cleanser; pat dry. • Apply a thin layer of Acnedap Gel twice daily (morning & evening) to entire affected area. • Duration: Use for at least 12 weeks to assess full efficacy; continue based on clinical response.
Papulopustular Lesions	• Cleanse skin; apply gel to lesions and surrounding skin twice daily. • Monitor for improvement over 4–6 weeks; combine with other topical/oral agents as needed.

Preparation: Wash hands and acne-prone areas; remove residual makeup or oil.
Application: Dispense pea-sized amount; gently spread over entire affected region (e.g., face, chest, back).
Frequency: Twice daily. If irritation or dryness occurs, reduce application to once daily.
Precautions: Avoid contact with eyes, mouth, and mucous membranes. Do not occlude treated areas unless directed. In patients with G6PD deficiency, use cautiously and monitor for hemolysis.

⚠️ Warnings & Side Effects

Common:

Dryness, peeling
Erythema, burning/stinging sensation
Contact dermatitis (mild)

Less Common:

Rare hemolysis in G6PD-deficient patients
Hypersensitivity reactions (rash, urticaria)

Serious (Rare):

Methemoglobinemia (monitor for cyanosis, fatigue) • Onset: weeks after initiation, particularly in G6PD-deficient individuals
Severe allergic dermatitis

Precautions:

G6PD Deficiency: Test before use; discontinue if signs of hemolysis appear (e.g., dark urine, jaundice).
Pregnancy/Breastfeeding: Use only if benefits outweigh risks; limited data available.
Pediatric Use: Safety not established in children < 12 years; monitor for systemic absorption.
Sun Exposure: Use sunscreen; Dapsone may increase photosensitivity.
Concurrent Topicals: Avoid combining with benzoyl peroxide or topical retinoids without physician guidance due to potential for increased irritation.

🏥 Storage Instructions

Store Acnedap Gel at 20–25°C (68–77°F) in its original tube. Protect from light and heat. Ensure cap is tightly closed after each use. Keep out of reach of children.

🌐 Global Availability & Purchasing

United States: Prescription required; branded as Aczone. Generic topical Dapsone gels are available.
United Kingdom & EU: Prescription-only; Dapsone gel formulations prescribed by dermatologists.
Australia: Prescription necessary; available under PBS or private script.

Importing Acnedap Gel from India can reduce costs. Ensure compliance with local personal importation regulations and maintain a valid prescription to avoid customs delays.

🔗 Authoritative Resources

🔗Related Acne Therapies (Indian Brands)

Clindac A Gel 15 g – Clindamycin Phosphate 1% for inflammatory acne.
Benzac 5% Gel 15 g – Benzoyl Peroxide 5% for comedonal and inflammatory lesions.
Aziderm 10% Gel 20 g – Azelaic Acid 10% for inflammatory and post-inflammatory hyperpigmentation.

🎥 Educational Video on Topical Dapsone in Acne

👨‍⚕️ Expert Insight: Dr. Priya Sharma, Dermatologist

“Topical Dapsone 5% offers a unique anti-inflammatory and antibacterial effect for acne patients, particularly those with inflammatory papules and pustules. It is generally well-tolerated, but monitoring G6PD status is critical to ensure safety.”