Name: Augmentin 375mg
SKU: 23576
Availability: InStock

✅ Active Ingredient Overview Table:

🔬 Active Ingredients:	Amoxicillin 250 mg + Clavulanic Acid 125 mg
💊 Indication:	Bacterial Infections (Respiratory, Skin, ENT, Urinary)
🇺🇸 US Brand Equivalent:	Augmentin
🏭 Manufacturer:	GlaxoSmithKline Pharmaceuticals Ltd (Founded: 2000)
📦 Packaging:	10 Tablets per Strip
🧪 Strength:	375 mg (250/125 mg)
🚚 Delivery Time:	6–15 days

🌿 What is Augmentin 375 mg?

Augmentin 375 mg combines amoxicillin, a broad-spectrum penicillin antibiotic, with clavulanic acid, a β-lactamase inhibitor. This formulation enhances amoxicillin’s efficacy against β-lactamase–producing bacteria, expanding its spectrum to include resistant strains of Staphylococcus, Haemophilus influenzae, Moraxella catarrhalis, and various anaerobes. Augmentin is indicated for acute otitis media, sinusitis, community-acquired pneumonia, skin and soft tissue infections, and urinary tract infections.

🧬 Pharmacology & Mechanism of Action

Component	Mechanism
Amoxicillin 250 mg	• Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs) → bactericidal activity.
Clavulanic Acid 125 mg	• Irreversibly inhibits β-lactamase enzymes produced by resistant bacteria → protects amoxicillin from degradation.
Pharmacokinetics	• Absorption: ~75–80% oral bioavailability; unaffected by food.
	• Distribution: Widely distributed; achieves therapeutic levels in middle ear fluid, sinuses, lung tissue.
	• Metabolism & Excretion: Excreted primarily unchanged via urine; clavulanic acid partially metabolized hepatically.
	• Half-Life: Amoxicillin: ~1 hour; Clavulanic acid: ~1 hour.

💡 Indications & Usage

Condition	Recommended Course
Acute Otitis Media (Ages ≥ 3 months)	375 mg twice daily for 5–7 days (increase to 875 mg twice daily for severe cases).
Acute Bacterial Sinusitis	375 mg twice daily for 10–14 days.
Community-Acquired Pneumonia (Adults)	875 mg twice daily for 7–10 days.
Skin & Soft Tissue Infections (Uncomplicated)	875 mg twice daily for 7–10 days.
Urinary Tract Infections (Uncomplicated)	875 mg twice daily for 7 days.

Administration: Swallow tablets whole with water; may take with or without food.
Missed Dose: If a dose is missed, take as soon as possible. Do not double dose within 3 hours of next scheduled dose.
Complete Course: Complete the full prescribed course to prevent resistance and recurrence.

⚠️ Warnings & Side Effects

Common Side Effects (≥1%):

Diarrhea, nausea, vomiting
Rash or urticaria
Dyspepsia

Less Common:

Hepatic enzyme elevations (transient)
Vaginal candidiasis (thrush)

Serious (Rare):

Clostridioides difficile–associated diarrhea (CDAD)
Severe hypersensitivity (anaphylaxis, angioedema)
Hepatic dysfunction, cholestatic jaundice

Precautions:

Allergy: Contraindicated in patients with a history of penicillin allergy or β-lactamase inhibitor hypersensitivity.
Hepatic Impairment: Use with caution; monitor liver function tests, especially in patients with hepatic disorders.
Renal Impairment: Dose adjustment required in creatinine clearance <30 mL/min; extend dosing interval to every 12–24 hours.
Pregnancy & Lactation: Category B; use only if clearly needed. Amoxicillin is excreted into breast milk; monitor nursing infants.
Pediatric Use: Approved in infants ≥3 months (weight-based dosing).

🏥 Storage Instructions

Store Augmentin 375 mg tablets at 20–25°C (68–77°F). Protect from moisture and excessive heat. Keep in original packaging until use. Discard any expired tablets. Keep out of reach of children.

🌐 Availability & Purchasing

United States: Prescription required; available as Augmentin in 250/125 mg and 500/125 mg strengths.
United Kingdom: Prescription-only; generics available.
Australia: Prescription necessary; available as generic amoxicillin/clavulanate.

Importing Augmentin 375 mg from India:
Purchasing from India can provide cost savings. Ensure a valid prescription, verify regulatory compliance for importation, and confirm product authenticity to avoid counterfeit products.

🔗 Authoritative Resources

Drugs.com: Augmentin Information

🔗 Related Antibiotic Therapies (Indian Brands)

Azithral 250 mg – Azithromycin by Alembic for atypical infections.
Doxy 100 mg – Doxycycline by Sun Pharma for Lyme and respiratory infections.

🎥 Educational Video on Amoxicillin/Clavulanate Therapy

👨‍⚕️ Expert Insight: Dr. Vandana Mehta, Infectious Disease Specialist

“Augmentin 375 mg is a versatile choice for community-acquired infections due to its enhanced coverage against β-lactamase–producing organisms. It’s essential to educate patients on completing the full course and monitoring for gastrointestinal side effects.”