Name: Betnovate N
SKU: 23220
Availability: InStock

✅ Active Ingredient Overview Table:

🔬 Active Ingredients:	Betamethasone Valerate 0.1% w/w, Neomycin Sulfate 0.5% w/w
💊 Indication:	Inflammatory Dermatoses with Secondary Bacterial Infection
🇺🇸 US Brand Equivalent:	N/A (Comparable: Diprolene for Betamethasone; Neosporin Topical)
🏭 Manufacturer:	GlaxoSmithKline Pharmaceuticals Ltd (Founded: 2000)
📦 Packaging:	20 g Ointment Tube
🧪 Strengths:	Betamethasone Valerate 0.1%, Neomycin Sulfate 0.5%
🚚 Delivery Time:	6–15 days

🌿 What Is Betnovate N Ointment?

Betnovate N combines Betamethasone Valerate, a potent topical corticosteroid, with Neomycin Sulfate, an aminoglycoside antibiotic. This formulation addresses inflamed skin conditions complicated by superficial Gram-negative and some Gram-positive bacterial infections—such as eczema, dermatitis, and intertrigo with secondary bacterial involvement. Betamethasone reduces pruritus, erythema, and inflammation by modulating cytokine production, while Neomycin inhibits bacterial protein synthesis by binding the 30S ribosomal subunit, preventing infection spread and promoting healing.

🧬 Pharmacology & Mechanism of Action

Component	Mechanism
Betamethasone Valerate 0.1%	• Binds glucocorticoid receptors → downregulates pro-inflammatory cytokines (IL-1, TNF-α) • Inhibits leukocyte infiltration, reduces vasodilation and edema
Neomycin Sulfate 0.5%	• Binds bacterial 30S ribosomal subunit → prevents translocation and protein synthesis → bactericidal against susceptible Gram-negative and some Gram-positive bacteria
Ointment Base	• Semi-occlusive emollient vehicle → enhances penetration, maintains moist wound environment for healing

💡 Indications & Application Guidelines

Condition	Application Regimen
Impetiginized Eczema / Intertrigo	• Gently cleanse and pat dry affected area. • Apply a thin layer of Betnovate N Ointment 1–2 times daily until infection resolves (usually 7–10 days). • Discontinue Neomycin component after 7 days; continue Betamethasone monotherapy if inflammation persists (max 14 days total).
Infected Psoriatic Lesions	• Cleanse area; apply Betnovate N to infected plaques twice daily for 7 days. • After bacterial control, switch to Betamethasone alone if needed.
Secondary Bacterial Dermatitis (e.g., Staphylococcal)	• Clean and dry; apply a thin layer twice daily until infection clears (5–7 days). • Monitor for resolution; if persistent, consider culture-directed systemic therapy.

Preparation: Wash hands and lesion with mild soap; pat dry.
Application: Dispense a pea-sized ribbon onto fingertip; spread gently over entire lesion ensuring full coverage.
Frequency: Begin with twice-daily application. If significant irritation occurs, reduce to once daily.
Precautions: Avoid eyes, mucous membranes, and open wounds larger than superficial; do not occlude unless directed.

⚠️ Warnings & Side Effects

Common:

Burning or stinging sensation at application site
Mild dryness or peeling
Folliculitis

Less Common:

Contact dermatitis (allergic)
Local hypersensitivity reactions

Serious (Rare):

Skin atrophy, striae, telangiectasia with prolonged steroid use
Superinfection with fungi or non-susceptible bacteria (e.g., Pseudomonas)
Ototoxicity (rare systemic absorption of Neomycin if applied to large areas)

Precautions:

Limit Betamethasone use to 14 days; Neomycin to 7 days.
Avoid use on extensive areas, open deep wounds, or around eyes.
Discontinue if signs of sensitization (rash, swelling, severe irritation) occur.
Use cautiously in pediatric and elderly patients to minimize systemic absorption.
Monitor for secondary infections; treat fungal or resistant bacterial infections appropriately.

🏥 Storage Instructions

Store Betnovate N Ointment at 20–25°C in its original tube. Protect from direct sunlight and moisture. Close cap securely after each use. Keep out of reach of children and pets.

🌐 Availability & Purchasing

United States: No direct branded combination; Betamethasone and Neomycin topical preparations are prescription-only separately. Combination compounding possible in specialized pharmacies under physician order.
United Kingdom & EU: Betnovate N available by dermatology prescription; combination topical steroid/antibiotic is prescription-only.
Australia: Prescription required; Neomycin-containing topicals may be restricted due to resistance concerns.

Importing Betnovate N from India requires adherence to personal importation regulations; ensure valid prescription and proper customs documentation to avoid delays.

🔗 Internal Links to Authoritative Resources

🔗 Internal Links to Related Topical Therapies (Indian Brands)

Betnovate Ointment – Betamethasone Valerate 0.1% for inflammatory dermatoses.
Betnovate C Cream – Betamethasone + Clioquinol for infected dermatoses.
Betnovate S Ointment – Betamethasone + Salicylic Acid for hyperkeratotic lesions.
Elocon Cream – Mometasone Furoate 0.05% for potent anti-inflammatory therapy.

🎥 Educational Video on Combination Topical Therapy

👩‍⚕️ Expert Insight: Dr. Sangeeta Patel, Dermatologist

“Betnovate N Ointment’s dual-action approach tackles both inflammation and secondary bacterial infection in a single application, speeding lesion resolution and improving patient comfort. Limiting antibiotic duration helps prevent resistance.”