Brufen 600mg

✅ Active Ingredient Overview Table:

🌡️ What is Ibuprofen 600 mg (Brufen 600)?

Brufen 600 mg is a high-strength ibuprofen formulation for managing severe pain and inflammation. As a nonsteroidal anti-inflammatory drug (NSAID), it nonselectively inhibits both COX-1 and COX-2 enzymes, reducing prostaglandin synthesis, thereby alleviating pain, swelling, and fever.

Pharmacodynamics studies show that a 600 mg dose achieves rapid pain relief within 30–60 minutes, with anti-inflammatory effects lasting up to 8 hours. This dose is ideal for acute postoperative, dental, or severe musculoskeletal pain.

For detailed prescribing and safety information, refer to the FDA label for Motrin and the Drugs.com monograph. The NHS Medicines A–Z entry and WHO Essential Medicines List offer additional guidance.

🧬 Pharmacology & Mechanism of Action

Ibuprofen’s COX inhibition mitigates prostaglandin-mediated nociception, inflammation, and pyrexia.

💡 Indications & Dosing

Always administer with food or milk to reduce gastrointestinal side effects. Avoid exceeding the maximum daily dose.

⚠️ Warnings & Side Effects

Common:

• Gastrointestinal discomfort (nausea, dyspepsia)
• Headache, dizziness
• Edema

Serious:

• Gastrointestinal bleeding, ulceration
• Increased cardiovascular risk (MI, stroke)
• Renal impairment, fluid retention

Use the lowest effective dose for the shortest duration. Monitor for GI, cardiovascular, and renal adverse events, especially in at-risk patients.

🏥 Storage Instructions

Store Brufen 600 mg at 20–25°C in original packaging, protected from moisture and light. Keep out of reach of children.

🌐 Availability & Purchasing

• USA: Prescription-only for 600 mg strength; lower strengths OTC.
• UK & EU: Prescription required; generic ibuprofen 600 mg available.
• Australia: Prescription and TGA import approval required.

Importing from India may decrease cost; ensure regulatory compliance and valid prescription.

🔗 Related High-Potency NSAIDs

• Ketoprofen 100 mg – potent NSAID.
• Diclofenac 100 mg SR – extended-release.
• Naproxen 500 mg – long-acting NSAID.
• Meloxicam 15 mg – preferential COX-2 inhibitor.
• Celecoxib 200 mg – selective COX-2 inhibitor.

🎥 Educational Video on High-Dose Ibuprofen

👩‍⚕️ Expert Insight: Dr. Priya Mehta, General Physician

“Brufen 600 mg provides powerful relief for acute severe pain. Ensure proper GI protection and monitor cardiovascular risk with high-dose NSAID therapy.”