Dapagliflozin

Oxra is an SGLT2 inhibitor developed by Sun Pharma , a global pharmaceutical leader founded in 1983 . It contains Dapagliflozin as the active ingredient and is used to manage type 2 diabetes and reduce cardiovascular risks in high-risk patients. Marketed as Farxiga® in some regions, Oxra lowers blood glucose by blocking glucose reabsorption in the kidneys, promoting its excretion in urine.

Key Features :

• Active Ingredient : Dapagliflozin (chemical formula: C₁₅H₁₄ClNO₅ ).
• Uses : Type 2 diabetes, heart failure with reduced ejection fraction (HFrEF), and prediabetes (off-label).
• Mechanism : Inhibits sodium-glucose cotransporter 2 (SGLT2), reducing renal glucose reabsorption.

Learn more about diabetes medications like Metformin, often paired with Oxra.

Manufacturer Background: Sun Pharma

Sun Pharmaceutical Industries , founded in 1983 , is a global leader in generic and branded medications. Their Oxra (Dapagliflozin) leverages its expertise in manufacturing high-quality generics at affordable prices. Sun Pharma’s commitment to innovation ensures Oxra meets WHO and FDA standards for efficacy and safety.

Key Milestones :

• 2012 : Dapagliflozin approved in the EU as Farxiga®.
• 2020 : Expanded approval for heart failure with reduced ejection fraction.
• Global Reach : Available in over 70 countries, including India, the US, and Europe.

Mechanism of Action and Clinical Benefits

How Oxra Works

• SGLT2 Inhibition : Blocks glucose reabsorption in the kidneys, lowering blood glucose and promoting urinary excretion.
• Cardiovascular Benefits : Reduces myocardial workload and improves diastolic function in heart failure.
• Weight Loss : Promotes mild weight loss via caloric excretion.

Unique Advantages

• Kidney Protection : Slows progression of chronic kidney disease (CKD).
• Dual Therapy : Effective for both diabetes and cardiovascular risk reduction.
• Cost-Effective : Generic Oxra offers savings compared to brand-name Farxiga® .

Global Availability and Generics

Brand vs. Generic Dapagliflozin

• Farxiga® (AstraZeneca) :
  • Cost : ~$200–$400/month in the US (varies by insurance).
  • Dosages : 5 mg and 10 mg tablets.
• Oxra (Sun Pharma) :
  • Cost : ~$30–$80/month (generic versions cost ~$15–$30/month).
  • Dosages : 5 mg and 10 mg tablets.

Purchasing Oxra Globally

• India :
  • Manufacturers : Sun Pharma and licensed partners.
  • Cost : ~₹150–₹400/month (INR).

How to Buy Oxra (Dapagliflozin)

United States

• Prescription Requirements : Mandatory from an endocrinologist or cardiologist.
• Purchase Options :
  • Pharmacies : CVS , Walgreens , Walmart .
  • Discount Programs : Sun Pharma’s Co-Pay Program reduces costs.
• Insurance : Covered by Medicare Part D and commercial plans.

United Kingdom

• NHS Availability : Prescribed for diabetes and heart failure under specific guidelines.
• Private Purchase : LloydsPharmacy , Boots , Superdrug .

Australia

• PBS Subsidy : Available under the Pharmaceutical Benefits Scheme .
• Pharmacies : Priceline , Chemist Warehouse .

Importing from India

• Legal Compliance : Follow FDA guidelines for personal use.
• Platforms : BuyAllMD and MedsGlobal offer verified generics.

Dosage, Administration, and Storage

Dosage Guidelines

Administration Tips

• Timing : Take with or without food, preferably at the same time daily.
• Titration : No dose adjustment required for mild renal impairment (eGFR ≥60 mL/min/1.73 m²).

Storage Guidelines

• Conditions : Store at room temperature (15°C–30°C).
• Avoid : Exposure to moisture or extreme temperatures.

Side Effects and Safety Considerations

Common Side Effects

• Genital yeast infections, urinary tract infections (UTIs), and mild dehydration.

Severe Risks

• Diabetic Ketoacidosis (DKA) : Rare but serious; presents with nausea, vomiting, and fruity breath odor.
• Volume Depletion : Risk of dizziness or hypotension, especially in the elderly.
• Hypoglycemia : Increased risk when combined with insulin or sulfonylureas.

Drug Interactions

• Avoid : Insulin or SGLT2 inhibitors (e.g., Jardiance® ) due to overlapping mechanisms.
• Caution With : Loop diuretics (risk of dehydration) and ACE inhibitors (blood pressure fluctuations).

Oxra vs. Other Diabetes Medications

Comparison with Metformin

Comparison with Empagliflozin (Jardiance®)

Comparison with Sitagliptin (Januvia®)

Off-Label Uses and Case Studies

Heart Failure Management

• Case Study : A patient with HFrEF saw improved ejection fraction and reduced hospitalizations after starting Oxra 5 mg/day .

Combination Therapy for Obesity

• Case Study : A patient with obesity and prediabetes lost 10% body weight using Oxra + lifestyle changes .

The Future of Oxra in Medicine

• Research Trends :
  • Investigating its role in non-alcoholic fatty liver disease (NAFLD) .
  • Exploring once-weekly formulations for better adherence.

Patient-Centric Insights

Adherence Strategies

• Medication Reminders : Apps like MyTherapy improve consistency.
• Side Effect Management : Probiotics for yeast infections, hydration to prevent UTIs.

Cost-Saving Tips

• Sun Pharma’s Assistance Program : Financial aid for uninsured patients.
• Mail-Order Pharmacies : Walgreens Specialty , CVS Caremark offer bulk discounts.

Conclusion

Oxra (Dapagliflozin) by Sun Pharma is a versatile therapy for type 2 diabetes and heart failure, offering glycemic control with proven cardiovascular benefits. Its generic availability and affordability make it accessible globally, though adherence to safety guidelines is critical. Always consult a healthcare provider for personalized treatment.

Explore Related Medications :

• Metformin : A first-line diabetes medication.
• Empagliflozin : Another SGLT2 inhibitor for heart health.
• Sitagliptin : A DPP-4 inhibitor for insulin-independent control.

Internal Links

• Metformin : Learn about its role in diabetes management.
• Empagliflozin : Compare with Oxra’s safety profile.
• Sitagliptin : Discover DPP-4 inhibitor mechanisms.

Authoritative Sources

• FDA : Dapagliflozin Drug Information .
• Drugs.com : Dapagliflozin Side Effects & Dosage .
• NHS : Dapagliflozin Guidelines .