Name: Dicorate ER
SKU: 13978
Availability: InStock

✅ Active Ingredient Overview Table:

🔬 Active Ingredient (Generic Name):	Divalproex Sodium
💊 Indication:	Epilepsy, Bipolar Disorder, Migraine Prophylaxis
🏭 Manufacturer:	Sun Pharmaceutical Industries Ltd. (Founded: 1983)
📦 Packaging:	10 Extended-Release Tablets per Strip
🧪 Strengths:	125 mg, 250 mg, 500 mg, 750 mg, 1000 mg
🚚 Delivery Time:	6–15 days

🌿 What is Divalproex Sodium (Dicorate ER)?

Dicorate ER delivers Divalproex Sodium, a stable compound of sodium valproate and valproic acid, formulated for extended release over 24 hours. This delivery system maintains steady therapeutic blood levels, reducing peak-related side effects such as dizziness and gastrointestinal discomfort. As a result, patients benefit from improved seizure control, mood stabilization in bipolar disorder, and effective migraine prevention with once-daily dosing.

Clinical trials have demonstrated that extended-release Divalproex provides similar efficacy to immediate-release formulations but with enhanced tolerability and adherence. Moreover, the ER form minimizes fluctuations in plasma concentration, leading to fewer breakthrough seizures and mood swings.

For authoritative prescribing details and safety information, refer to the FDA label for Depakote ER and the Drugs.com monograph. Additional guidance is also available through the NHS Medicines A–Z and the WHO Essential Medicines List.

🧬 Chemical Composition & Mechanism

Attribute	Detail
Chemical Formula	C₈H₁₅NaO₅ (for valproate ion)
Molecular Weight	264.24 g/mol
Bioavailability	~90%
Metabolism	Hepatic (UGT, CYP450)
Half-Life	8–16 hours (ER up to 24 hrs)

Divalproex increases brain levels of GABA, an inhibitory neurotransmitter, thus reducing neuronal excitability and stabilizing mood.

💡 Indications & Dosing

Condition	ER Dose (Once Daily)
Epilepsy (Seizure Disorders)	125–1000 mg based on weight and response
Bipolar Mania	750–1500 mg starting, adjust as needed
Migraine Prophylaxis	500–1000 mg

Initiate at lower end, then titrate weekly. Always monitor blood levels, liver function, and platelets.

⚠️ Warnings & Side Effects

Common:

GI upset (nausea, vomiting)
Tremor, weight gain
Drowsiness

Serious:

Hepatotoxicity
Pancreatitis
Thrombocytopenia
Teratogenicity (neural tube defects)

Use lowest effective dose. Conduct regular LFTs and CBCs. Avoid use during pregnancy unless essential.

🏥 Storage Instructions

Store at 20–25°C in a dry place. Keep in original container. Protect from moisture and children.

🌐 Availability & Purchasing

USA & Canada: Prescription-only; ER formulations available as Depakote ER.
UK & Europe: Prescription required; generics available.
Australia: Prescription needed; TGA-approved.

Import from India may reduce costs; ensure valid prescription and compliance with local regulations.

🔗 Related Therapies

Depakote ER – branded Divalproex ER.
Valproate Sodium – immediate-release option.
Lamotrigine – mood stabilizer alternative.
Topiramate – adjunctive antiepileptic.
Propranolol – migraine prophylaxis.

🎥 Educational Video on Divalproex Sodium

👨‍⚕️ Expert Commentary: Dr. Neeta Sharma, Neurologist

“Extended-release divalproex improves tolerability and adherence by reducing peak serum levels. However, careful monitoring of hepatic and hematologic parameters is critical.”