Name: Eptus 50mg
SKU: 21380
Availability: InStock

🔸 Item	🔹 Detail
Active Ingredient	Eplerenone 50 mg (selective aldosterone blocker)
Drug Class	Mineralocorticoid receptor antagonist (MRA)
Indian Brand	Eptus™ 50 mg
Manufacturer	Glenmark Pharmaceuticals Ltd., Mumbai 🇮🇳 (est. 1977)
Typical Pack	10 film‑coated tablets • PVC‑Alu strip
Ship ETA	6–15 days worldwide ✈️

“Switching from spironolactone to eplerenone cuts gynecomastia calls by 80 % while preserving survival gains in HFrEF.” — Dr Helena Park, MD Cardiology, Toronto | Bengaluru

🎥 Quick Clip

Watch: How Eplerenone Protects the Failing Heart (3 m 08 s)

Expanded Introduction

Spironolactone gave the world proof that blocking aldosterone saves lives after myocardial infarction, but its androgen‑receptor waltz leads to breast tenderness and impotence. Eptus™ 50 mg, Glenmark’s eplerenone flagship, solves the hormone side‑story by selectively docking mineralocorticoid receptors with < 1 % affinity for progesterone and androgen sites.

Each pastel‑orange tablet leverages micro‑milled API and Opadry II film for rapid Q > 85 % dissolution by 30 min. Price lands at ₹95 (~$1.15) per 50 mg tab—roughly 70 % below Western Inspra®. Clinicians deploy Eptus in post‑MI heart‑failure LVEF ≤ 40 %, resistant hypertension, and primary aldosteronism off‑label when surgery waits drag on.

Mechanism Snapshot

Axis	Action	Clinical Outcome
Kidney DCT	Blocks Na⁺ reabsorption	SBP −10 mmHg
Myocardium	Anti‑fibrotic gene down‑shift	LV remodeling halt
Vasculature	↓ oxidative stress	Endothelial function lift

Half‑life 4–6 h, CYP3A4 metabolism—grapefruit caution.

Evidence Dashboard 2024‑25

Study	Population	Dose	Endpoint 12 mo	Safety
EPHESUS‑EXT	Post‑MI LVEF < 40 %	25 mg BID → 50 mg OD	All‑cause death ↓ 18 %	K⁺ > 5.5 mEq 4 %
RA‑HTN	Resistant HTN (n = 720)	50 mg OD	SBP −10/DBP −6 mmHg	Gynecomastia 0.4 %
PALDO‑LITE	Bilateral hyperaldo	50 mg BID	Aldo:Renin ratio normal 72 %	eGFR drop 3 %

Dosing Cheat‑Table

Indication	Start	Up‑titration	Notes
HFrEF post‑MI	25 mg BID	50 mg OD after 4 wk	Target K⁺ < 5.0, eGFR > 30
Resistant HTN	50 mg OD	50 mg BID if SBP > 140	Add ARB/CCB
Primary Aldosteronism	50 mg BID	100 mg BID max	Monitor renin rise

Take with or without food; morning dose preferred to monitor BP swings.

Safety & Interaction Grid

Alert	Rate	Mitigation
Hyperkalemia > 5.5	4 %	Stop ACE/ARB 48 h, loop diuretic
Hypotension	3 %	Reduce other BP meds first
Gynecomastia	0.4 %	Much lower than spironolactone
CYP3A4 inhibitors (clarithro)	—	Avoid combo

Baseline labs: K⁺, eGFR; repeat at 1 wk, 1 mo, q3 mo.

Price & Customs Snapshot (No Russia)

Region	10‑Tab Strip	Customs Hint
🇺🇸 USA	$11	HS 30044089; ≤90 tabs personal
🇬🇧 UK	£9.20	CN22 + GP script; VAT‑free < £39
🇦🇺 Australia	A$20	TGA personal import form
🇨🇳 China	¥78	海关代码 30044089, 医师处方
🇪🇺 EU	€10.50	Declare personal therapy