Name: Metrogyl Gel
SKU: 23180
Availability: InStock

✅ Active Ingredient Overview Table:

🔬 Active Ingredient (Generic Name):	Metronidazole
💊 Indication:	Rosacea (Papulopustular), Perioral Dermatitis
🇺🇸 US Brand Equivalent:	Metrogel, Rosalox
🏭 Manufacturer:	J. B. Chemicals and Pharmaceuticals Ltd (Founded: 1973)
📦 Packaging:	15 g Tube
🧪 Strength:	2 % w/w
🚚 Delivery Time:	6 – 15 days

🌿 What Is Metronidazole 2 % Gel (Metrogyl)?

Metrogyl Gel harnesses 2 % metronidazole in a lightweight, non-greasy gel base. Metronidazole is a nitroimidazole antibiotic and antiprotozoal agent that exerts anti-inflammatory effects by scavenging reactive oxygen species and inhibiting neutrophil-generated reactive intermediates. When applied topically, it reduces inflammation, erythema, and papulopustular lesions in rosacea—typically manifesting as persistent facial redness, flushing, telangiectasia, and inflammatory bumps—and helps manage perioral dermatitis around the mouth, nose, and eyes.

Rosacea affects up to 5 % of adults worldwide, often impairing quality of life due to chronic flare-ups. Metrogyl’s gel formulation ensures even distribution over affected areas, rapid absorption, and minimal systemic exposure. Clinical trials show significant reduction in lesion count and erythema by week 4–6 of therapy. For detailed prescribing information, consult the FDA label for Metrogel and the Drugs.com metronidazole monograph. Additional guidance on rosacea management is available via the NHS Rosacea Overview and the WHO Essential Medicines List.

🧬 Pharmacology & Mechanism of Action

Attribute	Detail
Chemical Formula	C6H9N3O3
Molecular Weight	171.15 g/mol
Mode of Action	• Antimicrobial: reduction of nitro group by bacterial ferredoxin → free radical formation → DNA damage in anaerobes • Anti-inflammatory: scavenges reactive oxygen species, inhibits neutrophil function
Absorption	Minimal systemic absorption (<10 %); peak plasma levels low
Elimination	Primarily hepatic metabolism; excreted in urine

Metronidazole’s dual action—antibacterial and anti-inflammatory—makes it uniquely effective for inflammatory dermatoses where microbial colonization and chronic inflammation intersect.

💡 Indications & Application Guidelines

Condition	Application Regimen
Papulopustular Rosacea	• Cleanse face with gentle non-soap cleanser; pat dry. • Apply a thin layer of Metrogyl Gel to affected areas twice daily (morning & evening). • Continue for 6–12 weeks or as directed.
Perioral Dermatitis	• Wash and dry perioral region. • Apply a pea-sized amount of gel around mouth/nose area once or twice daily. • Continue 4–6 weeks; reassess if persistent.
Off-Label: Acne Vulgaris (Inflammatory)	• Apply thinly to inflammatory lesions once daily at night. • Use for 8–12 weeks alongside other acne measures as tolerated.

Preparation: Gently cleanse with lukewarm water or mild cleanser; pat dry.
Application: Dispense a pea-sized ribbon (≈ 1 cm) onto clean fingertips; gently spread evenly across the lesion field (entire cheeks, nose, forehead, chin for rosacea).
Frequency: Twice daily for rosacea; once or twice daily for perioral dermatitis. Adjust based on tolerance—if excessive dryness or irritation, reduce to once daily.
Additional Care: Avoid irritating cosmetics or harsh cleansers. Use broad-spectrum sunscreen daily to minimize UV-induced flare-ups.

Do not occlude unless instructed. Avoid eye contact; if accidental, rinse thoroughly. Discontinue use and consult a physician if severe irritation or signs of hypersensitivity occur.

⚠️ Warnings & Side Effects

Common (≤ 10 %):

Mild burning or stinging upon application
Dryness, peeling, transient erythema

Less Common (≤ 1 %):

Pruritus (itching), contact dermatitis
Paresthesia at application site (tingling)

Serious (Rare):

Extensive erythema and edema requiring treatment discontinuation
Hypersensitivity reactions: urticaria, angioedema (very rare)
Precautions:
• Avoid use in the first trimester of pregnancy unless benefits outweigh risks; limited data exist on dermatologic topical use in pregnant/lactating women.
• Use with caution in immunocompromised patients—monitor for signs of secondary infection.
• Do not use at the same time as other topical antibiotics on the same site.

🏥 Storage Instructions

Store Metrogyl Gel at 20 °C – 25 °C (68 °F – 77 °F) in its original tube. Protect from light and moisture. Discard 6 months after first opening. Keep out of reach of children and pets.

🌐 Availability & Purchasing

United States: Metrogel (Metronidazole 0.75 %) is prescription-only; 2 % gel is less common—usually available via compounding pharmacies.
United Kingdom & EU: Topical metronidazole gels (0.75 %–1 %) available by prescription; 2 % strength may require special order.
Australia: Topical metronidazole 0.75 % gel is prescription-only; higher concentrations generally not standard.

Patients may import Metrogyl 2 % from India under personal import regulations, provided a valid prescription is documented. Check local rules to ensure compliance and avoid delays.

🔗 Authoritative Resources

🔗 Related Dermatology Products (Indian Brands)

Clindac A Gel – Clindamycin 1 % gel for inflammatory acne.
Adapen Gel – Adapalene 0.1 % gel for comedonal/inflammatory acne.
Aziderm 10 % Gel – Azelaic Acid 10 % gel for acne & rosacea.

🎥 Educational Video on Topical Metronidazole in Rosacea

👨‍⚕️ Expert Insight: Dr. Arjun Malhotra, Dermatologist

“Topical metronidazole 2 % gel delivers robust anti-inflammatory benefits for papulopustular rosacea. By reducing free radicals and neutrophil-mediated damage, it often restores clear skin within weeks.”

Note: Always consult a dermatologist or healthcare provider before using Metrogyl Gel to ensure accurate diagnosis, proper prescription, and monitoring of treatment response.