Name: Niclosig
SKU: 21300
Availability: InStock

🏷️ Attribute	🔎 Detail
Generic Name	Niclosamide
Therapeutic Class	Salicylanilide anthelmintic (tapeworm killer)
Indications	Taenia saginata / solium (beef & pork tapeworm), Diphyllobothrium latum (fish tapeworm), Hymenolepis nana
Indian Brand	Niclosig™ 500 mg Tablet
Manufacturer	HAB Pharmaceuticals & Research Ltd, Mumbai, India (est. 1980)
WHO EML Reference	Section 6.1 – Niclosamide 500 mg
Presentation	10 film‑coated tablets per PVC‑Alu strip
Assay (IP 2024)	95 – 105 % of label claim
Global Dispatch Time	6 – 15 days ✈️

“Niclosamide remains unrivalled for adult tapeworm eradication—single dose, minimal absorption, stellar safety.” — Dr Anil Deshmukh, DTM&H, Consultant Parasitologist, London & Pune

🧪 How Niclosamide Works

🔬 Mechanistic Step	Parasitic Outcome
Uncouples oxidative phosphorylation in parasite mitochondria	Rapid ATP depletion → paralysis
Inhibits glucose uptake	Energy starvation accelerates death
Damages scolex & tegument	Promotes detachment from intestinal wall

2024 Cochrane Review (27 trials, n = 5 624) showed 96 % cure rate for Taenia saginata at 2 g single dose (p < 0.001).

🏭 HAB Pharmaceuticals & Research Ltd — Company Snapshot

1980: Founded in Mumbai by Dr Hashmat Alibhai Bham.
1992: First WHO‑GMP certificate for solid orals.
2010: Expanded to 14 manufacturing lines, 500+ SKUs.
2022: US‑DMF #034558 filed for niclosamide API.
2025: Exports to 70 countries; ISO 14001:2024 sustainability badge.

Niclosig™ tablets produced on Plant‑III Palghar; NIR‑PAT ensures blend uniformity ±2 %. Assay 99.1 % at 24‑month ICH stability.

🌍 Importing Niclosig™ 500 mg

🌎 Region	Status	Customs Pro‑Tip	Avg Landed Price*
🇺🇸 USA	Prescription (rarely stocked)	≤30 tabs, doctor’s note, HS 30049099	$0.42/tab
🇬🇧 UK	POM	CN22 + private Rx; VAT waived if <£39	£0.35/tab
🇦🇺 AU	Schedule 4	TGA personal‑import; ≤100 tabs	A$0.62/tab
🇪🇺 EU	Rx	CE268/2022 code 30049099	€0.40/tab
*Q2 2025 median bulk‑buy quotes

✈️ Traveller Hack: Keep a small bottle of saline laxative—expulsion of dead segments speeds symptom relief.

🏷️ Companion Indian Anthelmintics (Internal Links)

Praziquantel – Praziquantel 600 mg by Lupin; alternative for cestodes & schisto.
Bendex – Albendazole 400 mg by Cipla; broad nematode coverage.
Wormin – Mebendazole 100 mg by Cadila; paediatric formulation.
Ivecop – Ivermectin 12 mg by Menarini; STH & scabies synergy.
Levamisole – Levamisole 150 mg by Cipla; whipworm specialist.

💲 Price Ladder (₹ → USD @ ₹83/USD)

Qty (tabs)	FOB Mumbai	Reg. Air	Landed 🇺🇸	Save vs US List
50	₹550	₹620	$14.70	80 % ↓
100	₹1 000	₹750	$23.35	85 % ↓
500	₹4 400	₹850	$71.55	90 % ↓

📜 Dosing Playbook

Parasite	Age	Dose	Notes
Taenia saginata/solium, D. latum	Adults & ≥6 yrs	2 g once (4 × 500 mg)	Chew, swallow; follow with purge (MgSO₄)
H. nana	≥2 yrs	1 g/day × 7 days	Repeat in 10 days if eggs persist
Diphylobothriasis heavy load	Adults	2 g/day × 2 days	Combine with vitamin B₁₂ replenishment

Take after light breakfast; fasting ↓ GI tolerance.

🚦 Safety Matrix

Tier	Adverse Event	Management
🟢 Mild	Nausea, abdo discomfort	Split dose 1 g + 1 g q1h
🟡 Moderate	Dizziness, rash	Symptomatic; antihistamine if rash
🔴 Rare	Cyanosis (metHb)	Discontinue; methylene blue 1 mg/kg IV

Niclosamide is pregnancy category B (WHO) but lacks safety data in 1st trimester—avoid unless vital.

❄️ Storage & Travel Tips

Store 15 – 30 °C; avoid >65 % RH (tablet mottling).
Desert trek? Use aluminised zip‑pouch to block radiant heat.
Strip weight 1.1 g; ultra‑light backpack approved.

👨‍⚕️ Dr Anil Deshmukh’s Field Report

“In my 2024 refugee‑camp study (n = 436), a single 2 g Niclosig™ dose cleared 95.7 % Taenia infections. GI events mild; zero serious ADRs. Superior availability vs praziquantel in South Asia.”