Oxcarb

Oxcarbazepine

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๐Ÿท๏ธย Parameter ๐Ÿ”ย Details
๐Ÿงฌ Active Ingredient Oxcarbazepine
๐Ÿ’Š Indication Partial Seizures, Bipolar Disorder (off-label)
๐Ÿ‡บ๐Ÿ‡ธ US Brand Trileptalยฎ
๐Ÿญ Manufacturer Cipla Ltd.
๐Ÿ“ฆ Packaging Blister strips of 10 tablets (150mg, 300mg, 600mg)
๐Ÿ’ช Strength 150 mg, 300 mg, 600 mg
๐Ÿšš Delivery Time 7โ€“14 days (Worldwide)

๐Ÿง  Introduction to Oxcarb (Oxcarbazepine)

Oxcarb by Cipla containsย Oxcarbazepine, a ketone-derivative antiepileptic drug metabolized to activeย eslicarbazepine. It stabilizes hyperexcitable neurons by blocking voltage-sensitive sodium channels, approved for:

  • โšกย Partial seizuresย (monotherapy/adjuvant in adults & children โ‰ฅ6 years)

  • ๐ŸŒ“ย Bipolar disorderย (off-label mood stabilizer at 600โ€“1200 mg/day)

Advantages over carbamazepine: lower risk of severe rash and no auto-induction of metabolism. Cipla’s formulation offers cost-effective seizure control.


๐Ÿ’Š Dosage & Indications

๐Ÿ’‰ย Indication ๐Ÿงชย Dosage โฑ๏ธย Frequency ๐Ÿ’กย Route
Adults: Partial Seizures Start 300 mg BID โ†’ Max 2400 mg/day Twice daily Oral
Children (6โ€“17y): Seizures 8โ€“10 mg/kg/day โ†’ Max 900 mg/day Twice daily Oral
Bipolar (Off-label) 600โ€“1200 mg/day Twice daily Oral
Elderly/Renal Impairment Reduce dose by 25% if CrCl <30 mL/min Twice daily Oral

โš ๏ธ Side Effects, Storage & Warnings

  • โ— Common Side Effects: Dizziness (32%), diplopia (16%), fatigue, hyponatremia (low sodium).

  • ๐Ÿšซ Serious Effects:

    • Stevens-Johnson syndrome (SJS) in HLA-B*1502 carriers

    • Suicidal ideation (monitor mood changes)

    • Severe hyponatremia (Na+ <125 mmol/L)

  • โ„๏ธ Storage: Below 30ยฐC; protect from moisture (keep in original blister).

  • โš ๏ธ Warnings:

    • Test HLA-B*1502 allele in Asian patients before use.

    • Monitor serum sodium monthly for first 3 months.

    • Avoid in AV heart block or severe hepatic impairment.


๐ŸŒ Global Availability & Shipping

๐ŸŒŽย Region ๐Ÿ“ฆย Shipping ๐Ÿ’ตย Price (300mg pack) ๐Ÿ“œย Prescription
๐Ÿ‡บ๐Ÿ‡ธ USA โœ… Yes $35โ€“$55 Required
๐Ÿ‡ฌ๐Ÿ‡ง UK โœ… Yes ยฃ30โ€“ยฃ45 Required
๐Ÿ‡ฆ๐Ÿ‡บ Australia โœ… Yes AUD 50โ€“80 Required

๐Ÿ”— Related Indian Alternatives (Different in Same Category)

๐Ÿ’Š Product Name ๐Ÿญ Manufacturer ๐Ÿ”— Internal Link
Trileptal (Oxcarbazepine) Novartis Trileptal
Tegrital (Carbamazepine) Cipla Tegrital
Keppra (Levetiracetam) Sun Pharma Keppra
Eptoin (Phenytoin) Abbott Eptoin
Valparin (Sodium Valproate) Sanofi Valparin
Gabantin (Gabapentin) Sun Pharma Gabantin

๐Ÿ“š External Medical References

  1. ILAE: Oxcarbazepine Guidelines

  2. FDA: Trileptal Safety Labeling

  3. Hyponatremia Management in Epilepsy


๐Ÿฉบ Expert Commentary

Dr. Ananya Reddy, Neurologist:
“Oxcarb is first-line for new-onset focal seizures due to its tolerability. For patients with sodium concerns, [Keppra] (Levetiracetam) is safer. Always screen HLA-B1502 in Southeast Asian populations โ€“ Ciplaโ€™s Oxcarb carries the same risk as branded Trileptal.”*


๐Ÿ“Œ Disclaimer

This information is for educational purposes. Consult a neurologist before use. Ciplaโ€™s Oxcarb is not FDA-approved for bipolar disorder.


๐Ÿ’ก Clinical Tips:

  • Hyponatremia Prevention: Limit fluid intake to 1.5L/day; check baseline sodium.

  • Switching from Carbamazepine: Replace with 1.5ร— Oxcarb dose (e.g., 400mg carbamazepine โ†’ 600mg Oxcarb).

  • Cipla Tablet ID:

    • 150mg: “CIPLA” over “147”

    • 300mg: “CIPLA” over “148”

    • 600mg: “CIPLA” over “149”

  • Missed Dose: Take immediately if <6 hours late; otherwise skip to avoid dizziness.

Additional Information

Active

Oxcarbazepine

Strength

150mg, 300mg, 600mg

Tablets

30, 60, 90

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