| Active Ingredient (Generic Name) | Indication | US Brand* | Manufacturer | Packaging | Strength | Delivery Time |
|---|---|---|---|---|---|---|
| Pantoprazole 40 mg + Domperidone 30 mg | Acid reflux, GERD, dyspepsia with nausea | Protonix® (pantoprazole)* | Sun Pharma (India, founded 1983) | 15 capsules in blister | 40 mg + 30 mg | 6 to 15 days |
*Domperidone is not FDA‑approved; Protonix® represents the pantoprazole component only.
🌟 Instant Snapshot
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Brand name: Pantocid DSR (Delayed‑Release)
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Therapeutic class: PPI + Prokinetic combo
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Best for: Persistent heartburn with regurgitation, post‑prandial fullness, night‑time reflux
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Key advantage: Dual mechanism—acid suppression and faster gastric emptying
🧪 Chemical Blueprints
| Pantoprazole | Domperidone | |
|---|---|---|
| Molecular formula | C₁₆H₁₅F₂N₃O₄S | C₂₂H₂₄ClN₅O₂ |
| Drug class | Proton‑pump inhibitor | Peripheral dopamine‑2 antagonist |
| Mode of action | Irreversibly blocks H⁺/K⁺‑ATPase in parietal cells | Enhances GI motility, potentiates LES tone |
| pKa / logP | 3.9 / 1.5 | 7.9 / 3.7 |
| FDA status | Rx‑only (approved 2000) | Not approved (restricted under IND) |
Pantoprazole’s FDA label confirms once‑daily 40 mg equivalence to gastric pH > 4 for 24 h FDA Access Data, while multiple MHRA briefings flag domperidone’s cardiac‑risk‑driven dose cap of ≤30 mg per day hey.nhs.ukpanmerseyapc.nhs.uk.
💊 How Pantocid DSR Works (⚙️ inside your gut)
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🛡️ Pantoprazole shell: achieves >95 % acid blockade within 3 days.
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🚀 Domperidone core: accelerates gastric emptying, slashes reflux episodes by ~50 %.
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🧩 Synergy: less acid + less stasis = quicker mucosal healing and fewer night‑time symptoms.
🏥 Doctor’s Perspective
“I reserve Pantocid DSR for patients whose reflux is complicated by bloating or early satiety. Taken 30 minutes before breakfast, it normalises gastric kinetics without the CNS effects seen with metoclopramide.”
— Dr Rohan Mehta, DM (Gastroenterology), AIIMS Delhi
🛒 Buying Guide 🌐
🇺🇸 United States
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Status: Import‐only (personal use). Provide prescription + customs form 3299.
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Pantoprazole brand equivalence: Protonix® 40 mg; average US retail $11 per tablet.
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Price advantage: Pantocid DSR ≈ ₹119 (~$1.40) per strip 1mg → 90 % cheaper.
🇬🇧 United Kingdom
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Domperidone cap: ≤10 mg t.i.d. for nausea only (MHRA). Ship as “named‑patient import.”
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UK residents may import ≤3‑month supply with doctor’s letter.
🇦🇺 Australia
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PPI+prokinetic combos unregistered; Therapeutic Goods (TGA) allow Schedule 4 personal import under Section 19A. Retain prescription for border inspection.
✈️ Import from India—Checklist
| 📄 | Step |
|---|---|
| ✅ | E‑prescription stating “pantoprazole 40 mg + domperidone 30 mg,” qty ≤90 caps |
| 📦 | Use EMS or DHL‐Express; declare “non‑controlled Rx medicine for personal therapy.” |
| 💳 | Pay via international card or UPI-Remit; insure parcel up to $200 |
| 🕒 | Typical transit 6–15 days to US/EU; DHL tracking end‑to‑end |
🏭 Manufacturer Spotlight 🔆
| Sun Pharmaceutical Industries Ltd. | |
|---|---|
| Founded | 1983 by Dilip Shanghvi Wikipedia |
| HQ | Mumbai, India |
| Global rank | #4 specialty generics by revenue |
| GMP sites | 43 worldwide |
| FY‑24 Revenue | ~US $6.2 billion |
| Certifications | US‑FDA, EMA, TGA, WHO‑GMP |
📊 Pricing Matrix
| Region | 1 strip (10 caps) | 3‑month (90 caps) | Savings vs USA |
|---|---|---|---|
| India (retail) | ₹119 | ₹1 071 | – |
| US (import duty‑free) | ~$1.40 | ~$12.60 | ‑90 % |
| UK (duty‑free ≤£135) | ~£1.10 | ~£9.90 | ‑87 % |
| AU (GST exempt ≤A$1000) | A$1.85 | A$16.65 | ‑82 % |
📦 Packaging & Strengths
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Blister: PVC–Alu 10’s (moisture‑barrier).
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HDPE bottle: 30’s for hospital supply.
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Laser‑etched batch + expiry; QR codes verify authenticity via Sun Pharma Track‑&‑Trace.
🗒️ Prescription & Legal Points
| 🔑 | Requirement |
|---|---|
| USA | Rx only; import ≤90‑day supply; domperidone via IND. |
| UK | Private Rx; declare “patient‑specific.” |
| AU | Schedule 4; possess valid foreign Rx. |
| IND | Schedule H; pharmacist retains duplicate Rx for 2 years. |
💡 Dosage & Administration
| Indication | Typical dose | Timing |
|---|---|---|
| GERD with dyspepsia | 1 caps OD | 30 min before breakfast |
| Refractory reflux | 1 caps BID | Before breakfast & dinner |
| Short‑course rescue | 14 days | Review cardiac risk before extending ≥4 weeks |
🌡️ Storage Guide
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15 – 30 °C; avoid >40 °C (capsule shell may delaminate).
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Keep desiccant in blister until use.
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Protect from humidity >65 % RH.
⚠️ Side‑Effect Radar
| Frequency | Pantoprazole | Domperidone |
|---|---|---|
| Common (1–10 %) | Headache, flatulence | Dry mouth, abdominal cramps |
| Uncommon (0.1–1 %) | Arthralgia, pruritus | Breast tenderness, galactorrhoea |
| Rare (<0.1 %) | Hypomagnesaemia, C. difficile colitis | QT‑prolongation, ventricular arrhythmia hey.nhs.uk |
Tip: Baseline ECG for patients >60 y or on QT‑prolonging agents.
🔗 Indian Alternatives (Quick Links)
| 💠 Brand | Snapshot |
|---|---|
| Pan D | Alkem’s cap delivering same 40/30 mg ratio, gelatin‑free shell |
| Pantakind DSR | Mankind Pharma, blister of 10, price‑fighter option |
| Dompan | Torrent Pharma; domperidone‑heavy 30 mg tablet for stand‑alone motility aid |
| Pantop D | Aristo Labs, validated bioequivalence vs reference EU list |
| Pantodac DSR | Synokem; enteric hard‑gel caps with silicon‑dioxide desiccant |
📚 Authoritative Resources
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U.S. FDA Protonix® label update (2023) FDA Access Data
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WHO Model List of Essential Medicines (Pantoprazole, 22nd ed.)
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NHS Safety Alert on domperidone cardiac risk hey.nhs.uk
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Drugs.com monograph: Pantoprazole oral (accessed Apr 2025).
❓ FAQ
Q. Can I split Pantocid DSR capsules?
A. No—enteric coating will be destroyed; swallow whole.
Q. Is it safe in pregnancy?
Pantoprazole: Category B; Domperidone: avoid unless risk/benefit justified—consult OB.
Q. Will customs seize my order?
Personal‑use parcels with prescription + ≤90 days’ supply typically clear; attach invoice.
🏁 Key Takeaways
🔹 Pantocid DSR delivers double‑action relief in tough reflux.
🔹 Sun Pharma’s global GMP pedigree ensures consistent quality.
🔹 Personal import from India can cut costs by up to 90 %.
🔹 Monitor ECG when therapy >4 weeks in high‑risk patients.
🔹 Store below 30 °C; take 30 minutes before meals for peak benefit.





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