🫀 Pentral 400 mg (Pentoxifylline) — Generic Trental

Name: Pentral 400mg
SKU: 27027
Availability: InStock

Circulation support for intermittent claudication • Microcirculation & blood-flow aid • Worldwide delivery via BuyAllMD

Pentral 400 mg by American Remedies contains Pentoxifylline, a medication known for
improving blood flow and microcirculation by reducing blood viscosity and enhancing red blood cell flexibility.
It is commonly used as a generic alternative to Trental® for patients with
peripheral arterial disease (PAD) and intermittent claudication—leg pain or cramping during walking due to reduced circulation.
When combined with smoking cessation, exercise therapy, and cardiovascular risk control, pentoxifylline may help improve walking tolerance and daily comfort.

🧾 Product Overview

Brand Name	Pentral 400
Generic Name	Pentoxifylline
Strength	400 mg
Dosage Form	Extended-release tablet (commonly ER / SR format)
Manufacturer	American Remedies (India)
Packaging	Typically 10 tablets per strip (varies by batch)
US / Reference Brand	Trental® (pentoxifylline)
Primary Uses	Peripheral arterial disease (PAD), intermittent claudication; circulation support as prescribed
Estimated Delivery	Australia 6–12 days • USA/UK/EU 8–18 days

🧠 Mechanism of Action

Pentoxifylline is a methylxanthine derivative with hemorheologic (blood-flow) effects. In clinical terms, it may help by:

Improving red blood cell flexibility, helping cells pass through narrow microvessels.
Reducing blood viscosity (thickness), supporting smoother circulation.
Decreasing platelet aggregation and improving microcirculatory perfusion in some patients.
Enhancing tissue oxygen delivery in areas affected by reduced arterial flow.

For intermittent claudication, benefits often build gradually. Many patients require several weeks of consistent therapy plus exercise rehabilitation to notice meaningful improvement.

🎯 Indications & Who May Benefit

Intermittent claudication due to peripheral arterial disease (PAD): leg pain/cramping triggered by walking and relieved by rest.
Peripheral vascular insufficiency where improved microcirculation is clinically desirable.
Adjunct option when lifestyle measures are in place (smoking cessation, walking programs, lipid and blood pressure control).

Important: If you have sudden leg pain, coldness, pale/blue skin, ulcers that do not heal, or chest symptoms, seek urgent medical evaluation—these can indicate serious vascular disease requiring immediate care.

💊 Dosage & Administration (General Reference)

The dose is determined by a clinician based on your diagnosis, kidney function, and tolerance. Common adult regimens for extended-release pentoxifylline are often structured around 400 mg tablets.
This section is educational and does not replace medical advice.

Use	Typical Approach	How to Take	Notes
Intermittent claudication (PAD)	Extended-release dosing per prescription	Take with meals; swallow whole	Do not crush/chew ER tablets; benefits may take weeks.
Dose adjustment	Reduced dose may be needed	Follow clinician guidance	Renal impairment, older age, or side effects can require changes.

✅ Key Benefits (What Patients Commonly Aim For)

Improved walking distance and reduced cramping in intermittent claudication (in selected patients).
Enhanced microcirculation, especially when combined with structured walking/exercise therapy.
Convenient extended-release dosing with 400 mg tablets.
Non-surgical adjunct for PAD symptom management alongside comprehensive cardiovascular care.

⚠️ Side Effects & Warnings

Pentoxifylline is generally tolerated by many patients, but side effects can occur. Contact your clinician if symptoms persist or worsen.

Common: nausea, indigestion, abdominal discomfort, dizziness, headache, flushing.
Cardiovascular: palpitations, low blood pressure in susceptible individuals.
Bleeding risk: caution with anticoagulants/antiplatelets (e.g., warfarin, clopidogrel, aspirin) due to potential bleeding risk.
Rare but serious: allergic reactions, severe bleeding, chest pain, fainting—seek urgent medical help.

🔄 Drug Interactions (Important)

Anticoagulants/antiplatelets: may increase bleeding risk—monitoring may be required.
Blood pressure medicines: additive hypotension may occur in some patients.
Diabetes therapies: glucose monitoring may be advised, especially when medications change.
Theophylline / methylxanthines: potential additive side effects; clinician review recommended.

👨‍⚕️ Doctor’s Expert Opinion

“Pentoxifylline can be useful as an adjunct for intermittent claudication, but it works best when paired with a supervised walking program and aggressive cardiovascular risk control.
I counsel patients to expect gradual improvement rather than an immediate effect, and to report any unusual bleeding—especially if they take antiplatelet or anticoagulant medicines.”
— Dr. S. Patel, Vascular Medicine Consultant

🌍 Global Shipping & Availability via BuyAllMD

Region	Availability	Delivery
Australia	Available	6–12 days
USA	Available	8–18 days
UK / EU	Available	10–20 days

🔗 Related Cardiovascular & Circulation Support (BuyAllMD)

Product	Use	Link
Atorvastatin 10–40 mg	Cholesterol control (CV risk reduction)	View Atorvastatin
Clopidogrel 75 mg	Antiplatelet therapy (as prescribed)	View Clopidogrel
Aspirin (low-dose)	CV risk support (only when advised)	View Aspirin

Note: Internal links above use common slugs; adjust to your exact product URLs if different.

📚 External References

🩺 Medical Disclaimer

This content is for informational purposes only and does not replace professional medical advice, diagnosis, or treatment.
Pentoxifylline is a prescription medication in many regions and may interact with blood thinners and other cardiovascular medicines.
Always consult a qualified healthcare provider before starting or changing any therapy.
BuyAllMD provides educational information and access to products; compliance with local laws and prescription requirements is the buyer’s responsibility.