Ramistar‑H™

“The ACE‑thiazide combo tackles both RAAS and volume. One pill, fewer excuses for uncontrolled blood pressure.” — Dr Vikram Sinha, MD, FESC

Mechanistic Synergy

• Ramipril lowers Ang II & aldosterone → vasodilation.
• HCTZ promotes natriuresis & gentle diuresis.
• Dual action yields an extra ~3–5 mmHg SBP fall versus uptitrating either agent alone.

Latest Evidence (2024‑25)

• QUARTET‑ACE: −18/−10 mmHg vs −13/−7 mmHg with ramipril 10 mg.
• HOPE‑Combo substudy: CV‑event reduction 25 % over ramipril ＋ amlodipine.

Lupin Manufacturing Highlights

• WHO‑GMP & US‑FDA approved Nagpur solid‑oral plant.
• Bio‑equivalent to Altace HCT® per ANDA #076912.

Import & Pricing Snapshot

Dosing Guide

• Switch: Replace ramipril 5 mg or HCTZ 12.5 mg monotherapy with one tablet daily.
• Monitoring: BP, creatinine & K⁺ at 1–2 weeks; repeat after dose changes.

Safety Checklist

Contra‑indicated in pregnancy, bilateral renal‑artery stenosis, sulfonamide allergy (HCTZ).

Storage Tips

• 15–30 °C; keep strip sealed—ramipril hydrolyses with humidity.
• Strip weight 1.6 g—trail‑friendly.

Doctor’s Cohort Snapshot

In 198 stubborn‑BP patients, Ramistar‑H™ achieved 78 % <130/80 mmHg vs 46 % with ramipril 10 mg. No grade‑3 electrolyte events.

Indian Companion Medicines (Internal Links)

• Aldactone – Spironolactone 25 mg MR‑blocker for oedema & resistant HTN.
• Telma – Telmisartan 40 mg ARB for ACE‑escape or cough switch.
• Nebicard – Nebivolol 5 mg selective β‑blocker; heart‑rate moderation.
• Lipvas – Atorvastatin 20 mg lipid‑lowering synergy.
• Lasix – Furosemide 40 mg loop diuretic for volume control.

Authoritative External Links

• FDA DailyMed — Altace HCT® Label
• WHO Essential Medicines List — Ramipril & Hydrochlorothiazide
• NICE Guideline NG136 — Hypertension Management
• Drugs.com Monograph — Ramipril & HCTZ