Soliact 10mg

✅ Active Ingredient Overview Table:

🌿 What is Solifenacin 10 mg (Soliact)?

Soliact 10 mg contains Solifenacin Succinate, a potent and selective muscarinic M3 receptor antagonist designed to relax detrusor smooth muscle and reduce overactivity of the bladder. It addresses key OAB symptoms—urgency, frequency, and urge incontinence—enhancing patient quality of life through once-daily dosing.

Clinical trials reveal that the 10 mg dose offers superior reduction in daily incontinence episodes compared to the 5 mg dose, with up to a 70% decrease in leakage events over 12 weeks of therapy. Additionally, improvements in bladder capacity and voiding diary metrics demonstrate its robust efficacy.

For further prescribing and safety information, consult the FDA label for Vesicare, the Drugs.com monograph, the NHS Medicines A–Z entry, and the WHO Essential Medicines List.

🧬 Pharmacology & Mechanism of Action

Solifenacin’s high affinity for M3 receptors in the bladder minimizes central nervous system and salivary gland side effects, improving tolerability at the 10 mg dose.

💡 Indications & Dosing

Dose reduction to 5 mg recommended in patients with moderate hepatic or severe renal impairment. Consistent timing enhances plasma stability.

⚠️ Warnings & Side Effects

Common:

• Dry mouth
• Constipation
• Blurred vision

Serious:

• Urinary retention
• QT interval prolongation (rare)
• Severe hepatic impairment contraindicated

Monitor for anticholinergic effects, urinary retention, and cardiac conduction abnormalities. Avoid use in narrow-angle glaucoma.

🏥 Storage Instructions

Store Soliact 10 mg at 20–25°C in original blister. Protect from moisture and light. Keep out of reach of children.

🌐 Availability & Purchasing

• USA: Prescription-only (Vesicare 10 mg); branded and generic available.
• UK & EU: Prescription required; generic solifenacin available.
• Australia: Prescription and TGA approval required.

International import may lower costs; ensure compliance with regulations and valid prescription.

🔗 Related Overactive Bladder Therapies

• Soliact 5 mg – lower dose variant.
• Terol LA 4 mg – tolterodine ER.
• Mirabegron 50 mg – β3-adrenoceptor agonist.
• Darifenacin 7.5 mg – M3-selective antagonist.

🎥 Educational Video on OAB & Solifenacin

👩‍⚕️ Expert Insight: Dr. Kavita Desai, Urologist

“Solifenacin 10 mg delivers enhanced symptom control in OAB patients not adequately managed by the 5 mg dose. Regular monitoring for anticholinergic burden is essential.”