โ Active Ingredient Overview Table:
| ๐ฌ Active Ingredient (Generic Name): | Solifenacin Succinate |
|---|---|
| ๐ Indication: | Overactive Bladder (OAB): Urgency, Frequency, Urge Incontinence |
| ๐บ๐ธ US Brand: | Vesicare |
| ๐ญ Manufacturer: | Sun Pharmaceutical Industries Ltd. (Founded: 1993) |
| ๐ฆ Packaging: | 10 Tablets per Strip |
| ๐งช Strength: | 10 mg |
| ๐ Delivery Time: | 6โ15 days |
๐ฟ What is Solifenacin 10 mg (Soliten)?
Soliten contains 10 mg Solifenacin Succinate, a targeted M3 muscarinic receptor antagonist that reduces involuntary detrusor contractions, alleviating symptoms of overactive bladder (OAB). Clinical trials demonstrate significant reductions in urinary urgency and incontinence episodes with once-daily 10 mg dosing.
Compared to lower doses, Soliten 10 mg offers enhanced symptom control, with up to 75% reduction in leakage events. It maintains stable plasma levels for 24-hour efficacy.
๐งฌ Pharmacology & Mechanism of Action
| Attribute | Detail |
|---|---|
| Formula | C23H26N2O2โข2HCl |
| Weight | 480.38 g/mol (succinate salt) |
| Bioavailability | ~90% |
| Metabolism | Hepatic (CYP3A4) |
| Half-Life | ~45โ68 hours |
Solifenacin selectively antagonizes the M3 receptors in the bladder, minimizing off-target anticholinergic effects.
๐ก Indications & Dosing
| Condition | Dose |
|---|---|
| OAB Symptoms | 10 mg once daily; take with water; may be taken with or without food |
Reduce to 5 mg in patients with moderate hepatic or severe renal impairment.
โ ๏ธ Warnings & Side Effects
Common:
- Dry mouth
- Constipation
- Headache
Serious:
- Urinary retention
- Narrow-angle glaucoma exacerbation
- QT prolongation (rare)
Contraindicated in urinary retention, gastric retention, uncontrolled narrow-angle glaucoma, and severe hepatic impairment. Monitor patients for anticholinergic side effects.
๐ฅ Storage Instructions
Store Soliten 10 mg at 20โ25ยฐC in original blister. Protect from moisture and light. Keep away from children.
๐ Availability & Purchasing
- USA: Prescription-only (Vesicare); brand and generic available.
- UK & EU: Prescription required; generic solifenacin available.
- Australia: Prescription and TGA approval required.
International sourcing may reduce costs; ensure compliance with regulations and valid prescription.
๐ Related OAB Therapies
- Solifenacin 5 mg โ lower dose.
- Tolterodine ER 4 mg โ antimuscarinic.
- Mirabegron 50 mg โ ฮฒ3-agonist.
- Darifenacin 7.5 mg โ M3-selective.
๐ฅ Educational Video on OAB Management
๐ฉโโ๏ธ Expert Insight: Dr. Neha Kapoor, Urologist
โSolifenacin 10 mg offers a strong therapeutic option for patients with severe OAB symptoms, providing robust reduction in urgency and incontinence with a manageable side effect profile.โ




