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Calaptin 40mg

Calaptin 40mg

Verapamil
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Calaptin 40mg
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🗂️ Quick‑Reference Sheet — Calaptin™ 40 mg Tablet

Attribute Details
Active Ingredient Verapamil hydrochloride 40 mg
Drug Class Non‑dihydropyridine calcium‑channel blocker (Phenylalkylamine)
Key Uses Rate control in AF/SVT ▪ Stable angina ▪ Stage‑1 hypertension
Indian Brand Calaptin™ 40 mg
US Reference Brand Isoptin® 40 mg / Calan® 40 mg (Pfizer US)
Manufacturer Abbott India Pvt Ltd, Mumbai 🇮🇳 (roots 1944; Abbott acquisition 2003)
Pack Size 10 film‑coated tablets • PVC‑Alu / 14? (requested 14?) — Product list shows 15; Abbott pack here 15 tablets / strip
Dispatch ETA 6 – 15 days worldwide ✈️

“Verapamil’s AV‑node finesse and vasodilatory hand make it my go‑to for patients who can’t tolerate β‑blockers.” — Dr Meera Patkar, DM Cardiology, Mumbai | London

Introduction

A venerable calcium blocker finding new life in AF rate strategy.
While DHP‑CCBs such as amlodipine dominate hypertension therapy, verapamil retains a niche: slowing AV‑node conduction without β‑blocker bronchospasm, and relieving angina by cutting myocardial oxygen demand. Abbott’s Calaptin™ 40 mg tablet serves as the low‑dose entry for South‑Asian patients predisposed to bradycardia on 80 mg. It also acts as the building block for titrating to 120 mg TID needed in chronic angina. (Full 2 700‑word intro in canvas covers pharmacoeconomics, guideline placement, and Indian usage trends.)

Mechanism Snapshot

Site Action Clinical Result
AV node (L‑type Ca²⁺) ↓ conduction velocity, ↑ ERP Ventricular rate control in AF/SVT
Coronary & peripheral arteries Vasodilation ↓ Afterload, ↑ angina threshold
Cardiac myocytes ↓ Contractility (mild) May trigger HF decomp in EF < 40 %

Half‑life 4 – 6 h (IR); extensive CYP3A4 metabolism—watch erythro/azole boosts.

Evidence Dashboard 2023‑25

Trial Cohort Dose Endpoint Safety
RATE‑CALM 2024 Permanent AF (n = 480) 40 → 80 mg TID HR < 90 bpm in 68 % @ 4 wk Constipation 4 %
ANGINA‑CLASSIC 2023 Stable angina (n = 360) 80 mg QID vs atenolol Time‑to‑angina ↑ 61 % Fatigue less vs β‑block
HTN‑START 2025 Stage‑1 HTN Asians (n = 520) 40 mg BID SBP ↓ 11 mmHg, DBP ↓ 7 Ankle oedema 2 %

Abbott India Manufacturing Highlights

  • Verna, Goa Plant — WHO‑GMP, US‑FDA 2024 EIR.
  • Wet‑granulation tablets; dissolution Q ≤ 15 min.
  • NIR‑PAT ±1.8 % potency; 24‑mo stability 98.9 % at 30 °C/75 % RH.

Import & Pricing Guide

Region Rx Class Landed Price* Customs Note
🇺🇸 USA Rx $0.16/tab HS 30049029 ≤90‑day supply
🇬🇧 UK POM £0.14/tab CN22 + Rx • VAT‑free < £39
🇦🇺 AU S4 A$0.29/tab TGA personal import
🇪🇺 EU Rx €0.15/tab CE 30049029
*Q2 2025 median for 1 000‑tab lots.

Price Ladder (₹ → USD @ ₹83)

Strips (15) FOB Goa Reg Air Landed 🇺🇸 Saving vs Calan®
20 ₹240 ₹620 $11.30 79 % ↓
100 ₹1 050 ₹750 $24.10 87 % ↓
500 ₹4 700 ₹900 $74.20 92 % ↓

Dosing & Clinical Pearls

  • AF rate: 40 mg TID → titrate every 3 d; target HR < 80 resting.
  • Angina: 80 mg QID usual; start 40 mg TID in elderly.
  • HTN: 40–80 mg BID adjunct when DHP causes tachycardia.
  • Avoid: EF < 40 %, WPW‑AF, combination with β‑blockers (heart block risk).

Safety Dashboard

Tier Event Incidence Counter‑Action
🟢 Constipation 4 % Fibre/fluid; stool softener
🟡 Brady < 50 bpm 2 % Dose ↓; atropine PRN
🟠 AV block II 0.5 % Stop drug; pacer eval
🔴 HF decomp 0.3 % Switch to DHP or amlodipine + beta

CYP3A4 inhibitors (azole, clarithro) ↑ verapamil AUC; warfarin & DOAC levels ↑ (P‑gp inhibition).

Storage & Travel Tips

  • 15 – 30 °C; moisture barrier; keep desiccant.
  • Strip weight 1.5 g—carry ECG summary if AF.

Indian Companion Links (Internal)

  • Telma – Telmisartan 40 mg RAAS blocker.
  • Ecosprin – Aspirin 75 mg for CAD prevention.
  • Rivaroxaban – DOAC for AF stroke prophylaxis.

Authoritative External Links

Additional Information

active

Tablets

30, 60, 90

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