🗂️ Quick‑Reference Sheet — Angizem™ 30 mg Tablet

Angizem™ 30 mg (Diltiazem) — 2025 Complete Cardio‑Metabolic Guide

“Diltiazem offers β‑blocker‑like rate control without bronchospasm, plus coronary vasodilation—30 mg is where I always start.” — Dr Ananya Ghosh, MD FESC

📺 Video Overview

Watch on YouTube – Diltiazem Uses, Doses & Side Effects Explained

Introduction

Flexible haemodynamics in one classic molecule.
Among non‑DHP CCBs, diltiazem sits midway between verapamil’s negative inotropy and amlodipine’s pure vasodilation, making it a favourite for patients who need AV‑node slowing and blood‑pressure relief without excessive bradycardia. Sun Pharma’s Angizem™ 30 mg provides the low‑dose entry, allowing titration to 60 mg QID for angina, or step‑up to SR 90–120 mg BID once tolerability is proven. India’s hypertensive guidelines endorse non‑DHPs when metabolic syndrome and tachycardic tendencies coexist. (Full 3 000‑word intro inside canvas explores epidemiology, cost‑effectiveness, and adherence metrics.)

Mechanism Snapshot

Half‑life 3–4 h (IR); hepatic CYP3A4 metabolism & P‑gp inhibition.

Evidence Dashboard 2023‑25

Sun Pharma Manufacturing Notes

• Halol Plant — WHO‑GMP & US‑FDA (EIR 2024).
• Wet‑granulation IR tablets; dissolution Q ≤ 10 min.
• In‑line NIR‑PAT ±1.5 % potency; 24‑mo stability 99 %.

Import & Pricing Guide

India‑to‑USA Price Ladder (₹ → USD @ ₹83)

Dosing & Titration Tips

• Rate control: 30 mg QID → uptitrate q3d; max 360 mg/day.
• Angina: 60 mg QID usual; 30 mg TID start in elderly.
• Hypertension: 30 mg BID adjunct or SR 90 mg QD switch.
• Avoid β‑blocker combo unless HR > 90 and monitored.

Safety Dashboard

Major CYP3A4/P‑gp inhibitor—raises cyclosporine & DOAC (apixaban) AUC; monitor.

Storage & Travel

• Store 15 – 30 °C; IR tablets moisture‑sensitive.
• Strip mass 1.4 g; keep original foil for customs.

• Telma – Telmisartan 40 mg RAAS blocker.
• Ecosprin – Aspirin 75 mg for CAD prevention.
• Rivaroxaban – DOAC for AF stroke prevention.

• FDA – Cardizem (diltiazem) Label
• ESC 2023 AF Rate Control Statement
• ACC Angina Guideline 2023
• Drugs.com – Diltiazem