✅ Active Ingredient Overview Table:

🔬 Active Ingredient (Generic Name):	Bupropion Hydrochloride
💊 Indication:	Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), Smoking Cessation (off-label)
🇺🇸 US Brand:	Wellbutrin SR, Zyban
🏭 Manufacturer:	Sun Pharmaceutical Industries Ltd. (Founded: 1993)
📦 Packaging:	10 Extended-Release Tablets per Strip
🧪 Strength:	150 mg
🚚 Delivery Time:	6–15 days

🌿 What is Bupropion SR 150 mg (Bupron SR)?

Bupron SR 150 mg delivers a sustained-release formulation of Bupropion, an aminoketone antidepressant that inhibits norepinephrine and dopamine reuptake. This unique mechanism improves mood and motivation with a lower risk of sexual side effects compared to SSRIs.

Moreover, Bupropion’s dopaminergic action supports smoking cessation by reducing cravings and withdrawal symptoms, leading to higher quit rates in clinical studies. Bupropion SR 150 mg is typically started at one tablet in the morning to minimize insomnia, with dose titration based on response.

Clinical trials in MDD demonstrate significant symptom improvement by week 4, with remission rates up to 50%. In SAD, early symptom relief is observed during seasonal transitions, underlining Bupropion’s versatility.

🧬 Pharmacology & Mechanism of Action

Attribute	Detail
Chemical Formula	C13H18ClNO
Molecular Weight	239.75 g/mol
Bioavailability	~5–20% (first-pass metabolism)
Metabolism	Hepatic (CYP2B6)
Half-Life	21 hours (active metabolites)

Bupropion’s blockage of norepinephrine and dopamine transporters increases synaptic levels, enhancing neurotransmission in mood-regulating pathways.

💡 Indications & Dosing

Condition	Dose & Administration
Major Depressive Disorder (MDD)	Start 150 mg SR once daily in morning; may increase to 300 mg SR daily (150 mg BID) after 3 days
Seasonal Affective Disorder (SAD)	150 mg SR daily started in autumn, continued through winter
Smoking Cessation (off-label)	150 mg SR daily for 3 days; increase to 150 mg BID for 7–12 weeks

Administer Bupron SR with or without food in the morning to reduce risk of insomnia.

⚠️ Warnings & Side Effects

Common:

Insomnia, headache
Dry mouth, tremor
Sweating

Serious:

Seizure risk (dose-dependent)
Blood pressure elevation
Neuropsychiatric symptoms (mood changes)

Contraindicated in patients with seizure disorders, eating disorders, or abrupt alcohol/sedative withdrawal. Monitor blood pressure and warn patients about seizure risk and neuropsychiatric symptoms.

🏥 Storage Instructions

Store Bupron SR at 20–25°C in original blister packaging. Protect from moisture and light. Keep out of reach of children.

🌐 Availability & Purchasing

USA: Prescription-only (Wellbutrin SR); branded and generics.
UK & EU: Prescription required; Bupropion SR generics.
Australia: Prescription and TGA approval needed.

International purchasing may reduce costs; ensure compliance with local regulations and valid prescription.

🔗 Related Psychotropic Therapies

Venlafaxine ER 75 mg – SNRI.
Mirtazapine 15 mg – noradrenergic and specific serotonergic antidepressant.
Varenicline 1 mg – smoking cessation aid.
Modafinil 200 mg – off-label fatigue management.

🎥 Educational Video on Bupropion

👩‍⚕️ Expert Insight: Dr. Priya Mukherjee, Psychiatrist

“Bupropion SR is a versatile antidepressant that benefits patients with MDD and supports smoking cessation. Its unique pharmacology offers an alternative when sexual side effects or weight gain limit SSRI use.”