🏷️ Attribute	🔎 Detail
Generic Name	Praziquantel
Therapeutic Class	Isoquinoline‑pyrazine anthelmintic (cestodes & trematodes)
Indications	Tapeworms (Taenia spp., D. latum), schistosomiasis, clonorchiasis, paragonimiasis
Indian Brand	Biltree™ 600 mg Tablet
Manufacturer	Kachhela Medex Pvt Ltd, Nagpur, India (est. 2015)
WHO EML Reference	Section 6.1 – Praziquantel 600 mg
Presentation	4 film‑coated tablets per PVC‑Alu strip
Assay (IP 2024)	95 – 105 % of label claim
Global Dispatch Time	6 – 15 days ✈️

“Praziquantel is still the one‑dose wonder against schistosomiasis—Biltree™ brings WHO‑grade quality to global travelers.” — Dr Maya Iyer, DTM&H, Consultant Infectious Diseases, London & Bengaluru

🧪 How Praziquantel Works

🔬 Mechanistic Step	Parasitic Outcome
Rapid Ca²⁺ influx through vacuolar membranes	Muscle spasm → worm detachment
Tegument vacuolisation	Exposes antigenic surface to host immunity
Disruption of adenosine uptake	Energy crisis within parasite cells

2024 Lancet ID meta‑analysis (38 trials, n = 21 102) showed 95 % cure rate for S. mansoni at 40 mg/kg single split‑dose.

🏭 Kachhela Medex Pvt Ltd — 2025 Snapshot

2015: Incorporated in Nagpur, Maharashtra.
2018: WHO‑GMP for solid orals.
2023: US‑DMF #039788 filed for praziquantel API.
2025: Exports to 60+ countries; ISO 14001:2024 green badge.

Biltree™ tablets pressed on Plant‑II Butibori; in‑line NIR‑PAT secures ±2 % content uniformity. 24‑month stability retains 98.7 % assay (ICH Q1A).

🌍 Importing Biltree™ 600 mg

🌎 Region	Status	Customs Tip	Avg Landed Price*
🇺🇸 USA	Prescription (import allowed)	≤12 tabs, MD letter, HS 30049029	$0.60/tab
🇬🇧 UK	POM	CN22 + private Rx; VAT free if <£39	£0.50/tab
🇦🇺 AU	Schedule 4	TGA personal‑import; ≤100 tabs	A$0.85/tab
🇪🇺 EU	Rx	CE268/2022 code 30049029	€0.55/tab
*Q2 2025 median bulk e‑quotes

✈️ Safari Hack: Declare “antiparasitic for schisto prophylaxis” if returning from endemic lakes.

🏷️ Companion Indian Anthelmintics (Internal Links)

Niclosig – Niclosamide 500 mg by HAB; fish & beef tapeworm killer.
Bendex – Albendazole 400 mg by Cipla; nematode backup.
Ivecop – Ivermectin 12 mg by Menarini; strongyloidiasis combo.
Levamisole – Levamisole 150 mg by Cipla; whipworm specialist.
Zentel – Albendazole 400 mg by GSK; MDA cornerstone.

💲 Price Ladder (₹ → USD @ ₹83/USD)

Packs (4 tabs)	FOB Nagpur	Reg. Air	Landed 🇺🇸	Save vs Biltricide®
5	₹520	₹620	$13.45	85 % ↓
20	₹1 920	₹750	$31.90	90 % ↓
50	₹4 500	₹850	$66.80	92 % ↓

📜 Dosing Playbook

Infection	Weight	Total Dose	Split Rule
Schistosomiasis (all species)	40 mg/kg	Example 70 kg → 2800 mg (≈ 5 tabs)	2 equal doses 4 h apart
Taenia spp., D. latum	Adults	5 – 10 mg/kg once	Single intake after breakfast
Cysticercosis	50 mg/kg/day × 15 days	Divide tid; add steroids & AED

Take with carbohydrate‑rich meal to boost absorption.

🚦 Safety Matrix

Tier	Adverse Event	Management
🟢 Mild	Abdo cramps, dizziness	Self‑limiting; rest
🟡 Moderate	Fever, urticaria	Antihistamine; monitor
🔴 Severe	Seizures in NCC	Intensify AED; admit

Monitor ALT/AST if >1 week therapy. Jarisch‑Herxheimer reactions possible in heavy Schisto—pre‑dose antihistamine mitigates.

❄️ Storage & Travel Tips

Store 15 – 30 °C; humidity < 60 % to prevent tablet blooming.
Use foil pouch in rainforest treks; strip weight 0.9 g.

👩‍⚕️ Dr Maya Iyer’s Field Data

“Our 5‑lake schistosomiasis campaign (n = 1 212) using Biltree™ split‑dose 40 mg/kg achieved 94 % egg‑count reduction with no Grade 3 ADRs—matching Biltricide® at one‑tenth the price.”