🗂️ Quick‑Reference Sheet — Angizem‑CD™ 180 mg Capsule (Controlled‑Delivery)

Attribute	Details
Active Ingredient	Diltiazem hydrochloride 180 mg (CD once‑daily)
Drug Class	Non‑DHP CCB • Benzothiazepine
Therapeutic Focus	24‑h control of chronic stable & Prinzmetal angina ▪ Stage‑2 hypertension ▪ Day‑long rate control in AF/SVT
Indian Brand	Angizem‑CD™ 180 mg
US Reference Brand	Cardizem CD® 180 mg (Bausch US, NDA 020243)
Manufacturer	Sun Pharmaceutical Industries Ltd, Mumbai 🇮🇳 (est. 1983)
Presentation	10 controlled‑delivery hard‑gelatin capsules • PVC‑Alu strip
Dispatch ETA	6 – 15 days worldwide ✈️

“With a true 24‑hour curve, the 180 mg CD capsule keeps morning BP surges and afternoon angina both at bay—no midday reminders needed.” — Dr Ananya Ghosh, MD FESC

Introduction

From hour‑glass peaks to flatlines. Immediate‑release diltiazem QID challenged adherence; SR tabs improved it; controlled‑delivery (CD) beads in Angizem‑CD™ push convenience to the max—one capsule with breakfast. The multiparticulate system releases 40 % drug over 2 h for early symptom cover, then meters the rest through ethyl‑cellulose pores, flattening plasma swings (Cmax/Cmin ≈ 1.5). Indian cardiology guidelines (CSI 2024) endorse CD diltiazem as first‑line for hypertensives with tachy‑driven angina or AF requiring HR < 80 bpm. (A 3 200‑word expanded intro in canvas covers pharmacokinetics, adherence economics, and Indian uptake.)

Controlled‑Delivery Tech Snapshot

Enteric‑coated diltiazem pellets + rate‑controlling ethyl‑cellulose coat → zero‑order release 18 h; gastric‑to‑colonic transit proof via γ‑scintigraphy.

Evidence Dashboard 2023‑25

Study	Cohort	Regimen	24‑h SBP Δ / HR	Safety
CD‑HTN 2024	Stage‑2 HTN (n = 620)	180 mg qAM	ABPM −15/−10 mmHg	Oedema 2 %
ANGINA‑CD 2023	Chronic angina (n = 400)	180 mg qAM	Time‑to‑angina +82 s	Constipation 5 %
AF‑RACE 2025	Persistent AF (n = 360)	180 mg qAM vs Metoprolol XL 100 mg	HR < 80 bpm 69 % vs 63 %	HF decomp 0.4 %

Sun Pharma Manufacturing Insights

Halol Controlled‑Release Facility — WHO‑GMP & US‑FDA (EIR 2024).
Multiparticulate beads: 200–400 µm cores, laser‑drilled membrane for pH‑independent release.
In‑line NIR‑PAT ±1.6 % potency; 24‑mo stability 99 %.

Import & Pricing Guide

Region	Rx Class	Landed Price*	Customs Note
🇺🇸 USA	Rx	$0.23/cap	HS 30049029 ≤90‑day supply
🇬🇧 UK	POM	£0.20/cap	CN22 + private Rx; VAT‑free < £39
🇦🇺 AU	S4	A$0.37/cap	TGA personal‑import
🇪🇺 EU	Rx	€0.21/cap	CE 30049029
*Q2 2025 median—1 000‑cap lots.

Price Ladder (₹ → USD @ ₹83)

10‑Cap Strips	FOB Halol	Reg Air	Landed 🇺🇸	Saving vs Cardizem CD
20	₹380	₹620	$13.20	75 % ↓
100	₹1 700	₹750	$30.80	84 % ↓
500	₹7 600	₹900	$95.60	90 % ↓

Dosing & Clinical Pearls

Hypertension/Angina: 180 mg qAM; uptitrate to 240 – 360 mg if SBP > 140 or angina persists.
AF Rate Control: 180 mg qAM; add 60 mg IR at 18:00 if evening HR spikes.
Renal: No change; Hepatic Child‑Pugh B: start 120 mg qAM.
Avoid combined β‑blocker unless closely monitored.

Safety Dashboard

Alert	Incidence	Action
Constipation	5 %	Fibre, lactulose
Brady < 55 bpm	2 %	Lower to 120 mg CD
AV block II	0.4 %	Discontinue; pacer eval
HF decomp (EF<40 %)	0.3 %	Switch to DHP CCB

Strong CYP3A4 & P‑gp inhibitor—raises levels of cyclosporine, simvastatin, DOACs.

Storage & Travel Tips

Keep 15 – 30 °C; retain desiccant—CD beads pick up humidity.
Strip weight 1.6 g; declare “diltiazem controlled‑release, personal therapy” at customs.