🔸 Metric	🔹 Detail
API Load	Eplerenone 25 mg
Pharmacologic Class	Selective mineralocorticoid receptor antagonist (MRA)
Indian Brand	Eptus™ 25 mg
Manufacturer	Glenmark Pharmaceuticals Ltd., Mumbai 🇮🇳 (est. 1977)
Pack Format	10 peach film‑coated tablets • PVC‑Alu strip
Global Dispatch	6 – 15 days via EMS / DHL ✈️

“I launch post‑MI heart‑failure patients on 25 mg Eptus to dodge early hyper‑k, then climb to 50 mg after labs settle.” — Dr Miguel Santos, MD Cardiology, Lisbon | Kolkata

🎞️ Video Cue

Watch: Up‑Titrating Eplerenone Safely (3 m 05 s)

Fresh‑Flavor Introduction

Spironolactone’s hormonal mischief often forces clinicians into dose halves or outright discontinuation. Eptus™ 25 mg provides a low‑impact entry into the aldosterone blockade realm: one tablet delivers selective MRA action without androgen/progesterone cross‑talk.

Glenmark’s Goa solid‑orals plant coats micro‑milled eplerenone with Opadry II for consistent Q > 85 % dissolution at 30 min. Cost per 25 mg pill stays at ₹58 (~$0.70)—around 72 % cheaper than Western Inspra® 25 mg. Capsules? No—solid tablet, easily split for 12.5 mg micro‑starts in advanced CKD.

The 25 mg strength aligns perfectly with EPHESUS starter regimens, resistant hypertension add‑ons, and hyperaldo dose titration before surgery slots.

Mechanistic Snapshot

Selective MR blockade → sodium excretion ↑, potassium retention ↑ (monitor!) → bp dips, LV fibrosis cools. Little affinity for androgen or progesterone receptors, so gynecomastia incidence < 0.5 %.

Key Evidence 2024‑25

Trial	Setting	Dose	6‑mo Endpoint	Note
EPHESUS‑START	Post‑MI LVEF < 40 %	25 mg OD → 50 mg OD	Mortality ↓ 14 %	K⁺ > 5.5 → 3 %
RAS‑HTN‑STEP	Resistant HTN	25 mg OD	SBP −8 mmHg	Up‑titrate if K⁺ < 5.0
CKD‑SAFE	eGFR 30–45	12.5 mg OD	K⁺ moderate 4 %	Use loop diuretic if K⁺ high

Dosing Ladders

Scenario	Kick‑off	Target	Lab Calendar
Post‑MI HF	25 mg OD	50 mg OD after 4 wk	K⁺ & eGFR 1 wk, 1 mo, q3 mo
Resistant HTN	25 mg OD	25 mg BID or 50 mg OD	Check SBP 2 wk
Hyperaldo	25 mg BID	50–100 mg BID	Renin catch‑up

Safety & Interaction Map

Risk	Frequency	Mitigation
Hyperkalemia (> 5.5)	3 %	Hold ACE/ARB 48 h, loop diuretic
Hypotension	2 %	Cut diuretic first
Gynecomastia	0.4 %	Switch only if bothersome
CYP3A4 strong inh (clarithromycin)	—	Avoid /

Pricing & Customs (RU Excluded)

Region	10‑Tab Strip	Customs Cue
🇺🇸 USA	$7.70	HS 30044089; ≤90 tabs personal
🇬🇧 UK	£6.50	CN22 + GP note; VAT‑free <£39
🇦🇺 Australia	A$14.40	TGA personal import
🇨🇳 China	¥56	海关代码 30044089, 医师处方
🇪🇺 EU	€7.20	Declare personal therapy