✅ Active Ingredient Overview Table:

🔬 Active Ingredient (Generic Name):	Solifenacin Succinate
💊 Indication:	Overactive Bladder (OAB) Symptoms: Urgency, Frequency, Urge Incontinence
🇺🇸 US Brand:	Vesicare
🏭 Manufacturer:	Cipla Limited (Founded: 1935)
📦 Packaging:	15 Tablets per Strip
🧪 Strength:	5 mg
🚚 Delivery Time:	6–15 days

🌿 What is Solifenacin 5 mg (Soliact)?

Soliact contains Solifenacin Succinate, a selective M3 muscarinic receptor antagonist that relaxes bladder smooth muscle, reducing detrusor overactivity. It effectively manages OAB symptoms, improving patient quality of life by decreasing urinary urgency, frequency, and incontinence episodes.

Clinical studies show that Solifenacin 5 mg once daily significantly reduces incontinence episodes by up to 60% and decreases daytime voiding frequency. Its high selectivity for M3 receptors minimizes central and salivary gland side effects.

For comprehensive prescribing and safety information, see the FDA label for Vesicare and the Drugs.com monograph. Additional guidance is available via the NHS Medicines A–Z entry and the WHO Essential Medicines List.

🧬 Pharmacology & Mechanism of Action

Attribute	Detail
Chemical Formula	C23H26N2O2•2HCl
Molecular Weight	480.38 g/mol (succinate salt)
Bioavailability	~90%
Metabolism	Hepatic (CYP3A4)
Half-Life	~45–68 hours

Solifenacin’s antagonism of M3 receptors in the bladder detrusor muscle reduces involuntary contractions without significant central nervous system penetration.

💡 Indications & Dosing

Condition	Dose & Administration
Overactive Bladder Symptoms	5 mg once daily; may increase to 10 mg once daily based on efficacy and tolerability

Administer at the same time each day with or without food. Dose reduction to 5 mg recommended in severe renal or moderate hepatic impairment.

⚠️ Warnings & Side Effects

Common:

Dry mouth
Constipation
Blurred vision

Serious:

Urinary retention
QT prolongation (rare)
Severe hepatic impairment contraindication

Contraindicated in urinary retention, gastric retention, uncontrolled narrow-angle glaucoma, and severe hepatic impairment. Monitor for anticholinergic effects.

🏥 Storage Instructions

Store Soliact 5 mg at 20–25°C in original packaging. Protect from moisture and light. Keep out of reach of children.

🌐 Availability & Purchasing

USA: Prescription-only (Vesicare); branded and generic forms.
UK & EU: Prescription required; generics available.
Australia: Prescription and TGA approval required.

Importing from India may lower costs; ensure compliance with local regulations and valid prescription.

🔗 Related Overactive Bladder Therapies

Terol LA 4 mg – tolterodine ER.
Mirabegron 50 mg – β3-agonist.
Darifenacin 7.5 mg – M3-selective.

🎥 Educational Video on Solifenacin

👩‍⚕️ Expert Insight: Dr. Kavita Desai, Urologist

“Solifenacin’s M3 selectivity offers effective OAB symptom control with fewer central side effects. It’s a first-line oral therapy after behavioral modifications.”