✅ Active Ingredient Overview Table:

🔬 Active Ingredients:	Clindamycin Phosphate 1% w/w, Nicotinamide 4% w/w
💊 Indication:	Acne Vulgaris (Inflammatory & Non-Inflammatory Lesions)
🇺🇸 US Brand Equivalent:	There is no direct US equivalent; components available separately as Cleocin T (Clindamycin) and topical Niacinamide formulations
🏭 Manufacturer:	Abbott India Pvt. Ltd (Founded: 1948)
📦 Packaging:	20 g Tube
🧪 Strength:	Clindamycin 1% / Nicotinamide 4%
🚚 Delivery Time:	6–15 days

🌿 What is Faceclin Gel 1%/4%?

Faceclin Gel combines Clindamycin Phosphate, a lincosamide antibiotic effective against Cutibacterium acnes, with Nicotinamide (Vitamin B3), which has anti-inflammatory and sebum-regulating properties. This dual-action formulation targets both bacterial overgrowth and inflammatory processes underlying acne vulgaris. Clindamycin disrupts bacterial protein synthesis, reducing lesion counts, while Nicotinamide modulates inflammatory cytokines, enhances skin barrier function, and minimizes post-inflammatory hyperpigmentation.

Faceclin’s lightweight gel formulation ensures rapid absorption and minimal greasiness, making it suitable for use on oily and acne-prone skin. Clinical studies show combination therapy leads to faster reduction in both inflammatory and non-inflammatory lesions compared to monotherapy.

🧬 Pharmacology & Mechanism of Action

Component	Mechanism
Clindamycin Phosphate	• Binds to the 50S ribosomal subunit → inhibits bacterial protein synthesis → bacteriostatic/bactericidal against C. acnes.
• Reduces inflammation by decreasing neutrophil chemotaxis and bacterial lipase activity.
Nicotinamide (4%)	• Inhibits pro-inflammatory cytokines (e.g., IL-1, TNF-α) → reduces erythema and edema.
• Enhances ceramide synthesis → improves skin barrier function and reduces transepidermal water loss.
• Inhibits sebum production indirectly via lipid-regulating pathways, reducing microcomedo formation.
Gel Base	• Water-based, non-comedogenic gel → ensures rapid penetration, non-greasy feel, and minimal irritation.

💡 Indications & Application Guidelines

Condition	Application
Acne Vulgaris	• Cleanse face with gentle, non-comedogenic cleanser; pat dry.
• Apply a thin layer of Faceclin Gel to affected areas once or twice daily (morning & evening).
• Duration: Use continuously for at least 8–12 weeks to assess full efficacy.

Preparation: Ensure hands and treatment areas are clean and dry.
Application: Dispense pea-sized amount; spread evenly over acne-prone regions avoiding eye contour, lips, and mucous membranes.
Frequency: Begin with once daily (evening), increase to twice daily if well tolerated.
Combine Products: Use oil-free, non-comedogenic moisturizer to mitigate dryness; avoid irritating cleansers or exfoliants.
Sun Protection: Use broad-spectrum sunscreen during the daytime; both ingredients can increase photosensitivity.

⚠️ Warnings & Side Effects

Common:

Mild local irritation (dryness, peeling)
Erythema or transient burning/stinging sensation upon application

Less Common:

Pruritus
Contact dermatitis or hypersensitivity reactions (rash, swelling)

Serious (Rare):

Pseudomembranous colitis (systemic absorption extremely low; risk minimal but discontinue if severe diarrhea)
Severe allergic reaction (angioedema, anaphylaxis)

Precautions:

Hypersensitivity: Contraindicated in patients with known allergy to Clindamycin or Nicotinamide.
Secondary Infection: If skin integrity is compromised, treat infection prior to using Faceclin.
Pseudomembranous Colitis: Advise patients to discontinue and seek medical attention if persistent diarrhea occurs.
Pregnancy & Breastfeeding: Limited data; use only if potential benefit outweighs risk; consult healthcare provider.
Avoid Occlusion: Do not cover treated areas with occlusive dressings to reduce risk of irritation.

🏥 Storage Instructions

Store Faceclin Gel at 20°C–25°C in original tube. Protect from excessive heat and direct sunlight. Keep cap tightly closed. Discard 6 months after opening. Store out of reach of children.

🌐 Availability & Purchasing

United States: Clindamycin topical products and Nicotinamide formulations available separately by prescription or OTC; combination product not marketed.
United Kingdom & EU: Prescription-only; combination topical antibiotic and anti-inflammatory products exist under dermatology supervision.
Australia: Available by prescription; regulated for acne management; import allowed under TGA guidelines with valid prescription.

Importing Faceclin from India:
Purchasing Faceclin Gel directly from India offers cost savings. Ensure compliance with local import regulations, maintain valid prescription, and provide customs documentation to avoid delays.

🔗 Internal Links to Authoritative Resources

🔗 Internal Links to Related Topical Acne Therapies (Indian Brands)

Clindac A Gel 15 g – Clindamycin Phosphate 1% gel by Cipla Ltd.
Acnesol Gel 1% – Clindamycin Phosphate 1% gel by Systopic Laboratories.
Differin Gel 0.1% – Adapalene 0.1% topical retinoid by Galderma India.
Epiduo Gel 0.1%/2.5% – Adapalene/Benzoyl Peroxide combination by Galderma India.

🎥 Educational Video on Combination Acne Therapy

👩‍⚕️ Expert Insight: Dr. Sangeeta Patel, Dermatologist

“Faceclin Gel’s combination of Clindamycin and Nicotinamide addresses both bacterial proliferation and inflammation. Integrating niacinamide enhances skin barrier repair, reducing post-inflammatory marks and improving overall acne clearance.”