✅ Active Ingredient Overview Table:

🔬 Active Ingredient (Generic Name):	Methylprednisolone
💊 Indications:	Inflammatory & Autoimmune Conditions (e.g., Asthma, Rheumatoid Arthritis, Allergic Reactions, Dermatologic Disorders, Adrenal Insufficiency)
🇺🇸 US Brand Equivalent:	Medrol
🏭 Manufacturer:	Sun Pharmaceutical Industries Ltd (Founded: 1983)
📦 Packaging:	10 Tablets per Strip
🧪 Strengths:	4 mg / 8 mg / 16 mg
🚚 Delivery Time:	6–15 days

🌿 What is Methylprednisolone (Predmet)?

Methylprednisolone is a synthetic glucocorticoid with potent anti-inflammatory and immunosuppressive properties. As a single-ingredient oral tablet formulation, Predmet provides rapid relief from a variety of inflammatory, allergic, and autoimmune disorders such as asthma exacerbations, rheumatoid arthritis flares, severe allergic reactions, dermatological conditions (e.g., psoriasis, eczema), inflammatory bowel disease, and as a replacement therapy in adrenal insufficiency. Its ability to modulate gene transcription of pro-inflammatory mediators makes it essential in both acute and chronic management.

🧬 Pharmacology & Mechanism of Action

Attribute	Details
Chemical Formula	C22H30O5
Molecular Weight	374.47 g/mol
Mode of Action	• Enters cells and binds glucocorticoid receptors → translocates to nucleus
• Upregulates anti-inflammatory proteins (lipocortin-1) → inhibits phospholipase A2
• Downregulates pro-inflammatory cytokines (IL-1, TNF-α), COX-2 expression → reduces prostaglandin and leukotriene synthesis
• Suppresses immune cell activation and migration
Bioavailability	~80%
Metabolism & Excretion	Hepatic metabolism (CYP3A4) → excreted primarily in urine as inactive metabolites
Half-Life	Plasma half-life: ~2.8 hours; biological half-life: 18–36 hours

💡 Indications & Usage

Condition	Recommended Use
Asthma Exacerbations	• Acute Relief: 4 mg once daily for 3–5 days, then taper;
• Chronic Management: 4–8 mg once daily; adjust based on severity and prednisone equivalence.
Rheumatoid Arthritis	• Flare Control: 8–16 mg once daily for 7–14 days, then taper by 4 mg every 3–7 days until maintenance dose or discontinuation.
Allergic Reactions (e.g., Severe Urticaria, Anaphylaxis Adjunct)	• 8 mg once daily for 5–7 days; adjust based on clinical response.
Dermatologic Disorders (Psoriasis, Eczema Flares)	• 4–8 mg once daily for 5–10 days; taper quickly to avoid rebound.
Inflammatory Bowel Disease (Ulcerative Colitis, Crohn’s)	• 16 mg once daily for induction (7–10 days), taper by 4 mg weekly to lowest effective dose.
Adrenal Insufficiency (Replacement Therapy)	• Maintenance: 4 mg in morning; 2 mg in afternoon (divided dosing); adjust per endocrinologist.

Administration: Swallow tablets whole with water; may take with food to minimize gastrointestinal irritation.
Tapering: Gradual dose reduction is essential to prevent adrenal insufficiency and HPA axis suppression.
Monitoring: Regular assessment for symptom control, blood glucose, electrolytes, and bone density in chronic use.

💊 Dosage Recommendations

Strength	Typical Starting Dose	Tapering Strategy
4 mg	4 mg once daily	Reduce by 1–2 mg every 3–5 days until discontinuation
8 mg	8 mg once daily	Reduce by 2–4 mg every 5–7 days to maintenance dose or off therapy
16 mg	16 mg once daily	Reduce by 4 mg weekly until target maintenance or discontinuation

Dosing must be individualized based on indication, disease severity, concomitant therapies, and patient response.

🩺 Storage Guidelines

Store Predmet tablets at 20°C–25°C (68°F–77°F).
Protect from moisture and excessive heat.
Keep strips in original packaging until use to maintain tablet integrity.
Discard any expired or discolored tablets.

⚠️ Possible Side Effects

Common (Dose-Dependent):

Hyperglycemia
Fluid retention, hypertension
Weight gain, increased appetite
Mood changes (euphoria, insomnia, depression)
Acne, hirsutism

Less Common:

Gastric irritation, dyspepsia
Osteoporosis with prolonged use
Cataracts, glaucoma
Muscle weakness, proximal myopathy

Serious (Rare):

Adrenal suppression (secondary adrenal insufficiency)
Peptic ulcer disease, gastrointestinal bleeding
Infectious complications (masked infections)
Thromboembolism

Precautions:

Infection Risk: Avoid live vaccines; monitor for latent infections (e.g., TB).
Metabolic Effects: Monitor blood glucose, lipids.
Bone Health: Supplement calcium and vitamin D; consider bisphosphonates in long-term use.
Ophthalmologic Monitoring: Regular eye exams for cataract/glaucoma risk.
Tapering: Do not abruptly discontinue after ≥2 weeks to prevent adrenal crisis.

🌐 Availability & Purchasing

United States: Prescription required; branded as Medrol. Generic methylprednisolone tablets (4 mg, 8 mg, 16 mg) widely available.
United Kingdom & EU: Prescription-only; generic tablets available; specialist guidance for tapering regimens.
Australia: TGA-approved; prescription necessary; import permitted under PBS or private prescription.

Importing Predmet from India:
Purchasing Predmet from India can offer significant cost savings. Ensure compliance with local import regulations, maintain valid prescription, and verify authenticity (batch certification) to avoid counterfeit products.

🔗 Authoritative Resources

Drugs.com: Methylprednisolone Monograph

🔗 Related Corticosteroid Therapies (Indian Brands)

Betnesol (Betamethasone) 0.5 mg – Oral corticosteroid by GSK.
Dexona (Dexamethasone) – Potent glucocorticoid by Merck.

🎥 Educational Video on Methylprednisolone Therapy

👨‍⚕️ Expert Insight: Dr. Ananya Verma, Rheumatologist

“Methylprednisolone offers rapid control of many inflammatory and autoimmune flares. Its potency requires careful dosing and tapering to minimize side effects. Monitoring metabolic and bone health is crucial during prolonged therapy.”