🏷️ Parameter	🔍 Details
🧬 Active Ingredients	Bictegravir 50mg + Emtricitabine 200mg + Tenofovir Alafenamide 25mg
💊 Indication	HIV-1 Infection (First-line ART for adults/adolescents ≥25kg)
🇺🇸 US Brand	Biktarvy®
🏭 Manufacturer	Hetero Drugs Ltd.
📦 Packaging	30 tablets in 1 HDPE bottle
💪 Strength	50mg/200mg/25mg per tablet
🚚 Delivery Time	7–14 days (Worldwide)

🧬 Introduction to Taffic

Taffic by Hetero Drugs is a cutting-edge HIV regimen combining:

🧩 Bictegravir 50mg (INSTI: integrase strand transfer inhibitor)
🧬 Emtricitabine 200mg (NRTI: cytidine analog with dual HIV/HBV activity)
🛡️ Tenofovir Alafenamide 25mg (TAF: nephro-safe prodrug of tenofovir)

Approved for HIV-1 treatment in patients ≥25kg, this 30-tablet bottle offers:

✅ Once-daily dosing (any food/timing)
✅ Superior renal/bone safety vs. TDF-based regimens
✅ High genetic barrier to resistance
✅ First-line WHO-recommended regimen
❗ Caution with concomitant rifampicin

Hetero’s generic version provides affordable access to this gold-standard therapy.

💊 Dosage & Indications

💉 Indication	🧪 Dosage	⏱️ Frequency	💡 Notes
Adults ≥25kg	1 tablet	Once daily	With or without food
Adolescents (25-35kg)	Not recommended	–	Use pediatric formulations
Renal Impairment	Avoid if eGFR <30 mL/min	Contraindicated	TAF accumulation risk
HBV Co-infection	Never discontinue abruptly	–	Monitor for HBV flare

⚠️ Side Effects, Storage & Warnings

❗ Common Side Effects:
- Headache (10%)
- Diarrhea (7%)
- Nausea (6%)
🚫 Rare Serious Effects:
- Immune reconstitution syndrome
- Lactic acidosis (0.1%)
- Hepatomegaly with steatosis
❄️ Storage: 15–30°C; keep bottle tightly closed (desiccant included).
⚠️ Critical Warnings:
- Contraindicated with rifampicin or carbamazepine
- Test for HBV before initiation
- Monitor eGFR/urine protein annually

🌍 Global Availability & Shipping

🌎 Region	📦 Shipping	💵 Price (30-tablet bottle)	📜 Prescription
🇺🇸 USA	✅ Yes	$90–$150	Required
🇬🇧 UK	✅ Yes	£70–£120	Required
🇦🇺 Australia	✅ Yes	AUD 130–190	Required

🔗 Related Indian Alternatives (Different in Same Category)

💊 Product Name	🏭 Manufacturer	🔗 Internal Link
Dolutranz (Dolutegravir/Tenofovir)	Mylan	dolutranz
Tenof-EM (Tenofovir/Emtricitabine)	Hetero	tenof-em
Viraday (Efavirenz/FTC/TDF)	Cipla	viraday
Tavin-EM (TAF/FTC)	Cipla	tavin-em
DoloVir (Dolutegravir/TAF/FTC)	Hetero	dolovir
Covihope-D (Dolutegravir/Ritonavir)	Hetero	covihope-d

📚 External Medical References

🩺 Expert Commentary

Dr. Meena Krishnan, HIV Researcher:
“Taffic’s Bictegravir has negligible neuropsychiatric effects compared to Efavirenz-based regimens. For patients on rifampicin TB therapy, switch to [dolovir] (Dolutegravir-based). Hetero’s bottle includes oxygen absorber to maintain TAF stability in humid climates.”

📌 Disclaimer

This information is not medical advice. Use under physician supervision. Hetero’s Taffic must not be used for HBV monotherapy.

💡 Clinical Protocol:

HBV Co-infection Protocol:
- Test HBV surface antigen before starting
- If positive: Monitor LFTs monthly ×3, then quarterly
- Never interrupt therapy (risk of fatal hepatitis flare)
Bottle Specifications:
- White HDPE bottle with induction seal
- Tablet ID: “H” logo + “TFC” engraving
- Oxygen scavenger sachet (do not remove)
Drug Interactions:

Concomitant Drug Risk Action

Rifampicin ↓ Bictegravir levels 75% Contraindicated

Antacids ↓ Bictegravir absorption Separate by 2 hours

Dabigatran ↑ Bleeding risk Monitor aPTT
Renal Monitoring Schedule:

Parameter Frequency Action Threshold

eGFR Baseline, Annual Decline >25%

Urine Protein/Creatinine Annual Ratio >200 mg/g

Serum Phosphate If symptoms <2.0 mg/dL