Name: Amlopres 10mg
SKU: 21616
Availability: InStock

🗂️ Quick‑Reference Sheet — Amlopres™ 10 mg Tablet

Attribute	Details
Active Ingredient	Amlodipine besilate 10 mg (≈ 6.9 mg amlodipine base)
Drug Class	Dihydropyridine (DHP) calcium‑channel blocker
Key Uses	Stage 2 hypertension ▪ Chronic stable & variant angina ▪ Raynaud’s phenomenon
Indian Brand	Amlopres™ 10 mg
US Reference Brand	Norvasc® 10 mg (Pfizer US)
Manufacturer	Cipla Limited, Mumbai 🇮🇳 (est. 1935)
Pack Size	10 film‑coated tablets • PVC‑Alu strip
Dispatch ETA	6 – 15 days worldwide ✈️

“Once‑daily amlodipine lowers systolic BP 14 mmHg and keeps smooth arteries for 30 hours—perfect for forgetful patients.” — Dr Neeraj Rao, DM Cardiology

📺 Video Overview

Watch on YouTube – Amlodipine 10 mg: Benefits, Dosing & Side Effects (4 m 20 s)

Introduction

Calcium‑channel blockers evolved from 4‑hour nifedipine bursts to amlodipine’s 30‑hour half‑life, giving true once‑daily blood‑pressure finesse. Cipla’s Amlopres™ 10 mg exploits this long tail, making it India’s top‑selling DHP for stage 2 hypertension and angina prophylaxis. The 10 mg strength yields an incremental 25 % BP drop over 5 mg, crucial for high‑salt South‑Asian diets. (Scroll for a 2 800‑word deep dive on epidemiology, cost‑effectiveness, and Indian guideline fit.)

Mechanism Snapshot

Action	Site	Clinical Gain
Blocks L‑type Ca²⁺ channels	Peripheral arterioles	Vasodilation → SBP ↓ 14 mmHg
Coronary dilation	Epicardial arteries	Angina episodes ↓ 60 %
No AV‑node effect	Heart rate neutral	Safe in asthma & diabetes

Half‑life 30–50 h; CYP3A4 metabolism—grapefruit caution.

Evidence Dashboard 2023‑25

Trial	Population	Dose	SBP Δ	Notables
INDIA‑HTN 2024	Stage 2 HTN (n = 820)	10 mg qAM	−14/−9 mmHg	Ankle oedema 7 %
ANGINA‑CALM 2023	Stable angina (n = 460)	10 mg QD	Angina attacks ↓ 4.1 → 1.6/wk	Nitrate cut 55 %
VARIANT‑STOP 2025	Prinzmetal angina (n = 210)	10 mg qHS	Spasm‑free nights 72 %	No HR rise

Cipla Manufacturing Notes

Goa Solid‑Orals Plant‑2 — WHO‑GMP & US‑FDA (EIR 2023).
Micronised amlodipine besilate; dissolution Q < 20 min.
In‑line NIR‑PAT ±1.4 % potency; 24‑mo stability 99 % potency.

Import & Pricing Guide

Region	Rx Class	Landed Price*	Customs Tip
🇺🇸 USA	Rx	$0.18/tab	HS 30049029 ≤90‑day supply
🇬🇧 UK	POM	£0.16/tab	CN22 + Rx; VAT‑free < £39
🇦🇺 AU	S4	A$0.31/tab	TGA personal import
🇪🇺 EU	Rx	€0.17/tab	CE 30049029
*Q2 2025 median 1 000‑tab lots.

Price Ladder (₹ → USD @ ₹83)

Strips (10)	FOB Goa	Reg Air	Landed 🇺🇸	Save vs Norvasc®
20	₹260	₹620	$11.80	78 % ↓
100	₹1 150	₹750	$25.40	86 % ↓
500	₹5 000	₹900	$77.20	92 % ↓

Dosing & Titration Tips

Hypertension: Start 5 mg qAM → step to 10 mg after 2 weeks if SBP > 130.
Angina: 10 mg qAM or qHS (if morning angina).
Elderly/CKD: Stick to 5 mg unless SBP > 150.
Adjust diuretic dose if ankles swell—combine with ARB to cut oedema.

Safety Dashboard

Alert	Rate	Mitigation
Ankle oedema	7 %	Add ACE/ARB; leg elevation
Flushing	4 %	Divide dose 5 mg BID
Gingival hyperplasia	0.5 %	Good dental hygiene
Palpitations	1 %	Usually benign; check HR