Angizem™ CD 180mg

🗂️ Quick‑Reference Sheet — Angizem‑CD™ 180 mg Capsule (Controlled‑Delivery)

“With a true 24‑hour curve, the 180 mg CD capsule keeps morning BP surges and afternoon angina both at bay—no midday reminders needed.” — Dr Ananya Ghosh, MD FESC

📺 Video Overview

Watch on YouTube – Diltiazem CD 180 mg: Benefits & Precautions (4 m 41 s)

Introduction

From hour‑glass peaks to flatlines. Immediate‑release diltiazem QID challenged adherence; SR tabs improved it; controlled‑delivery (CD) beads in Angizem‑CD™ push convenience to the max—one capsule with breakfast. The multiparticulate system releases 40 % drug over 2 h for early symptom cover, then meters the rest through ethyl‑cellulose pores, flattening plasma swings (Cmax/Cmin ≈ 1.5). Indian cardiology guidelines (CSI 2024) endorse CD diltiazem as first‑line for hypertensives with tachy‑driven angina or AF requiring HR < 80 bpm. (A 3 200‑word expanded intro in canvas covers pharmacokinetics, adherence economics, and Indian uptake.)

Controlled‑Delivery Tech Snapshot

Enteric‑coated diltiazem pellets + rate‑controlling ethyl‑cellulose coat → zero‑order release 18 h; gastric‑to‑colonic transit proof via γ‑scintigraphy.

Evidence Dashboard 2023‑25

Sun Pharma Manufacturing Insights

• Halol Controlled‑Release Facility — WHO‑GMP & US‑FDA (EIR 2024).
• Multiparticulate beads: 200–400 µm cores, laser‑drilled membrane for pH‑independent release.
• In‑line NIR‑PAT ±1.6 % potency; 24‑mo stability 99 %.

Import & Pricing Guide

Price Ladder (₹ → USD @ ₹83)

Dosing & Clinical Pearls

• Hypertension/Angina: 180 mg qAM; uptitrate to 240 – 360 mg if SBP > 140 or angina persists.
• AF Rate Control: 180 mg qAM; add 60 mg IR at 18:00 if evening HR spikes.
• Renal: No change; Hepatic Child‑Pugh B: start 120 mg qAM.
• Avoid combined β‑blocker unless closely monitored.

Safety Dashboard

Strong CYP3A4 & P‑gp inhibitor—raises levels of cyclosporine, simvastatin, DOACs.

Storage & Travel Tips

• Keep 15 – 30 °C; retain desiccant—CD beads pick up humidity.
• Strip weight 1.6 g; declare “diltiazem controlled‑release, personal therapy” at customs.

Indian Companion Medicines (Internal Links)

• Ecosprin – Aspirin 75 mg CAD prophylaxis.
• Rivaroxaban – DOAC for AF stroke Prevention.

Authoritative External Links

• FDA – Cardizem CD 180 mg Label
• ESC 2023 Hypertension Guideline
• ACC 2023 Angina Guideline
• Drugs.com – Diltiazem CD

SEO‑Ready Snippets

Titles (≤ 80 char)

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5. Controlled‑Release CCB – How It Beats IR Tablets
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Meta Descriptions (≤ 180 chars)

1. Angizem‑CD™ 180 mg gives 24‑h diltiazem control. ABPM −15/−10 mmHg, angina +82 s. Dosing, price ladder & CYP3A4 alerts—April 2025 guide.
2. Buy Sun’s CD diltiazem at $0.23/cap—save 90 % vs Cardizem CD®. Import codes, humidity storage & AV‑block safety grid included.
3. One breakfast capsule replaces 4 IR tabs. See release tech, AF study data & internal links to RAAS blockers and DOAC.
4. Import Angizem‑CD™ to USA/UK/AU in 6–15 days. VAT waiver, grapefruit warning & cross‑border FAQ provided.
5. Concerned about constipation? Fibre fixes & dose‑split tips in our cardio‑expert article.
6. April 2025 SEO guide: Sun WHO‑GMP plant, CD‑HTN trial, cost‑effect metrics & traveller hacks.

Disclaimer: Educational content; consult a cardiologist before starting or adjusting controlled‑release diltiazem.