Name: Brufen 400mg
SKU: 22602
Availability: InStock

✅ Active Ingredient Overview Table:

🔬 Active Ingredient (Generic Name):	Ibuprofen
💊 Indication:	Moderate to Severe Pain, Inflammation, Fever
🇺🇸 US Brand:	Advil, Motrin
🏭 Manufacturer:	Abbott India Pvt Ltd (Founded: 1944)
📦 Packaging:	15 Tablets per Strip
🧪 Strength:	400 mg
🚚 Delivery Time:	6–15 days

🌡️ What is Ibuprofen 400 mg (Brufen 400)?

Brufen 400 mg provides a higher-dose option of Ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID) that inhibits COX-1 and COX-2 enzymes, thereby reducing prostaglandin production. This results in effective relief of moderate to severe pain, inflammation, and fever in conditions like musculoskeletal injuries, dental pain, dysmenorrhea, and postoperative pain.

Pharmacokinetics indicate rapid absorption, with peak plasma levels achieved within 1 hour. The 400 mg dose delivers sustained relief, allowing dosing every 6–8 hours as needed, up to 1,200 mg per day for short-term management.

For complete prescribing and safety information, consult the FDA label for Motrin and the Drugs.com monograph. Additional guidance is available via the NHS Medicines A–Z entry and the WHO Model List of Essential Medicines.

🧬 Pharmacology & Mechanism of Action

Attribute	Detail
Chemical Formula	C13H18O2
Molecular Weight	206.28 g/mol
Bioavailability	~80–100%
Metabolism	Hepatic (CYP2C9)
Half-Life	~2 hours

Ibuprofen’s COX inhibition reduces prostaglandin-mediated pain and inflammation, and exerts antipyretic effects via direct hypothalamic action.

💡 Indications & Dosing

Condition	Dose
Moderate to Severe Pain	400–600 mg every 6–8 hours as needed (max 1,200 mg/day)
Inflammation (Arthritis, Bursitis)	400 mg twice daily with food
Dysmenorrhea	400 mg initial, then 400 mg every 6–8 hrs (max 1,200 mg/day)
Fever	400 mg every 6–8 hours (max 1,200 mg/day)

Always administer with food or milk to minimize GI irritation. Adjust dosing interval based on clinical response.

⚠️ Warnings & Side Effects

Common:

Dyspepsia, nausea, abdominal pain
Headache, dizziness
Edema

Serious:

GI bleeding, ulcers
Increased cardiovascular risk (MI, stroke)
Renal impairment, fluid retention

Use the lowest effective dose for the shortest duration. Evaluate GI and cardiovascular risk factors before and during treatment.

🏥 Storage Instructions

Store Brufen 400 mg at 20–25°C in a cool, dry place, protected from light. Keep out of reach of children.

🌐 Global Availability & Purchasing

USA: Prescription required for 400 mg tablets; OTC ibuprofen available in lower strengths.
UK & EU: Prescription-only; generic ibuprofen 400 mg available.
Australia: Prescription needed; follow TGA guidelines for import.

Importing from India may reduce costs; ensure compliance with local regulations and maintain a valid prescription.

🔗 Related NSAID Options

Meloxicam 15 mg – preferential COX-2 inhibitor.
Celecoxib 200 mg – COX-2 selective agent.

🎥 Educational Video on High-Dose Ibuprofen

👩‍⚕️ Expert Insight: Dr. Ravi Shah, General Practitioner

“Brufen 400 mg offers powerful relief for moderate to severe pain. It’s crucial to counsel patients on proper GI protection and cardiovascular risk management when using high-dose NSAIDs.”