โ Active Ingredient Overview Table:
| ๐ฌ Active Ingredients: | Adapalene 0.1% w/w, Clindamycin Phosphate 1% w/w |
|---|---|
| ๐ Indication: | Acne Vulgaris (Inflammatory & Non-Inflammatory Lesions) |
| ๐บ๐ธ US Brand Equivalent: | No direct combination; Adapalene (Differin), Clindamycin (Cleocin T) separately |
| ๐ญ Manufacturer: | Abbott India Pvt Ltd (Founded: 1948) |
| ๐ฆ Packaging: | 15 g Tube |
| ๐งช Strength: | Adapalene 0.1% / Clindamycin 1% |
| ๐ Delivery Time: | 6โ15 days |
๐ฟ What is Faceclin AT Gel 0.1%/1%?
Faceclin AT Gel combines Adapalene, a topical retinoid that normalizes follicular keratinization and reduces comedone formation, with Clindamycin Phosphate, a lincosamide antibiotic effective against Cutibacterium acnes. This synergistic formulation targets both the hyperkeratinization and bacterial colonization that drive acne pathogenesis. Faceclin ATโs lightweight gel base ensures rapid absorption, minimal greasiness, and suitability for oily, acne-prone skin. Clinical data show combination therapy speeds lesion reduction and prevents new comedones more effectively than monotherapy.
๐งฌ Pharmacology & Mechanism of Action
| Component | Mechanism |
|---|---|
| Adapalene 0.1% | โข Binds to retinoic acid receptors (RAR-ฮฒ, RAR-ฮณ) โ modulates gene transcription โ normalizes keratinocyte differentiation โ prevents microcomedone formation โข Anti-inflammatory by reducing arachidonic acid metabolites and neutrophil chemotaxis. |
| Clindamycin 1% | โข Binds to 50S ribosomal subunit โ inhibits bacterial protein synthesis โ bacteriostatic/bactericidal against C. acnes โข Reduces inflammation by decreasing neutrophil chemotaxis and cytokine release. |
| Gel Base | โข Water-based, non-comedogenic gel โ ensures even distribution, rapid penetration, and less residue than creams. |
๐ก Indications & Application Guidelines
| Condition | Application |
|---|---|
| Acne Vulgaris | โข Cleanse face with a gentle, non-comedogenic cleanser; pat dry. |
| โข Apply a thin layer of Faceclin AT Gel to affected areas once daily in the evening. | |
| โข Duration: Use consistently for at least 8โ12 weeks to assess full efficacy. |
- Preparation: Wash hands and treatment area; avoid harsh soaps or alcohol-based cleansers before application.
- Application Technique: Dispense pea-sized amount; spread evenly over acne-prone regions, avoiding eyes, lips, and mucous membranes.
- Frequency: Start once daily in evening; if tolerated after 2โ4 weeks, may consider morning application as clinically indicated.
- Adjunctive Measures: Use oil-free, non-comedogenic moisturizer to mitigate dryness; avoid abrasive exfoliants and keep sun exposure minimal, applying broad-spectrum sunscreen daily.
โ ๏ธ Warnings & Side Effects
Common:
- Erythema, dryness, peeling
- Mild burning or stinging at application site
Less Common:
- Pruritus
- Contact dermatitis (allergic)
Serious (Rare):
- Severe irritant dermatitis requiring discontinuation
- Secondary bacterial skin infection if skin barrier compromised
Precautions:
- Pregnancy & Breastfeeding: Limited data; use only if benefits outweigh risks.
- Sun Sensitivity: Adapalene increases photosensitivity; apply sunscreen and avoid excessive sun exposure.
- Avoid Eye Contact: If accidental, rinse thoroughly with water.
- Allergen Information: Contraindicated in patients allergic to Adapalene, Clindamycin, or excipients.
- Concurrent Therapy: Avoid simultaneous use of other topical retinoids or abrasive products to reduce irritation.
๐ฅ Storage Instructions
Store Faceclin AT Gel at 20ยฐCโ25ยฐC. Protect from excessive heat and direct sunlight. Keep tube tightly closed when not in use. Discard 6 months after opening. Keep out of reach of children.
๐ Availability & Purchasing
- United States: Components available separately; combination product not marketed.
- United Kingdom & EU: Prescription-only; typically provided as separate topical agents or compounding.
- Australia: Prescription required; import may be allowed under TGA guidelines with valid prescription.
Importing Faceclin AT from India:
Purchasing Faceclin AT Gel from India can lower costs. Ensure valid prescription, comply with local import regulations, and provide customs documentation to avoid delays.
๐ Internal Links to Authoritative Resources
- Drugs.com: Adapalene Monograph
- Drugs.com: Clindamycin Monograph
- NHS: Acne Vulgaris Overview and Management
๐ Internal Links to Related Topical Acne Therapies (Indian Brands)
- Differin Gel 0.1% 15 g โ Adapalene 0.1% standalone by Galderma India.
- Clindac A Gel 15 g โ Clindamycin Phosphate 1% gel by Cipla Ltd.
- Epiduo Gel 0.1%/2.5% 30 g โ Adapalene and Benzoyl Peroxide combination by Galderma India.
- Neoprosone Gel 15 g โ Clindamycin 1% + Benzoyl Peroxide 5% combination by Wallace Pharma.
- Benzac AC 5% Gel 15 g โ Benzoyl Peroxide 5% for comedonal and inflammatory acne by Glenmark Pharma.
๐ฅ Educational Video on Combination Retinoid/Antibiotic Therapy
๐ฉโโ๏ธ Expert Insight: Dr. Priya Mehta, Dermatologist
โFaceclin AT Gelโs synergistic action of Adapalene and Clindamycin tackles both keratinocyte turnover and bacterial proliferation. Starting with once-daily evening application minimizes irritation, and patients often see improvements within 6โ8 weeks.โ




