Flutibact Ointment

✅ Active Ingredient Overview Table:

🌿 What Is Fluticort–Mupirocin Combination (Flutibact Ointment)?

Inflammatory dermatoses such as eczema or psoriasis frequently become secondarily infected by Gram-positive organisms—most commonly Staphylococcus aureus. In these “impetiginized” or “bacterial-exacerbated” lesions, a topical agent that simultaneously suppresses inflammation and eradicates bacteria accelerates healing, reduces pruritus, and prevents scarring. Flutibact Ointment combines fluticasone propionate (a potent topical corticosteroid) and mupirocin (a selective topical antibiotic) to address both aspects in one convenient formulation.

Fluticasone propionate 0.05% exerts anti-inflammatory, antipruritic, and vasoconstrictive effects by binding glucocorticoid receptors in skin cells, downregulating pro-inflammatory cytokines (e.g., IL-1, TNF-α), and inhibiting phospholipase A₂ activity. Mupirocin 2% targets bacterial isoleucyl–tRNA synthetase, blocking protein synthesis in susceptible Gram-positive cocci, including methicillin-resistant Staphylococcus aureus (MRSA). This dual action yields rapid reduction in erythema, scaling, and exudate while eradicating pathogenic bacteria.

For more information on fluticasone’s safety and mechanism, see the FDA label and the Drugs.com monograph for fluticasone. For mupirocin details, visit the Drugs.com mupirocin monograph. Additional guidance on impetigo and infected dermatitis management is available at the NHS Impetigo Overview and the WHO Essential Medicines List.

🧬 Pharmacology & Mechanism of Action

Fluticasone’s corticosteroid activity addresses the host’s inflammatory cascade, while mupirocin’s selective bacteriostatic/bactericidal action eradicates local pathogens. The ointment base promotes occlusion, optimizing penetration of both actives into the stratum corneum and epidermis.

💡 Indications & Application Guidelines

1. Preparation: Wash hands thoroughly and cleanse the affected area with a gentle cleanser.
2. Application: Squeeze a pea-sized ribbon of ointment onto a sterile fingertip or cotton swab. Lightly spread over the lesion, ensuring the entire margin is covered.
3. Frequency: Twice daily—morning and evening. If significant irritation develops, reduce to once daily at bedtime.
4. Nasal Use (Off-Label): Use a gloved fingertip or sterile cotton swab to apply to anterior nares; do not occlude. Strict hand hygiene before and after application is essential.

Do not bandage or occlude unless directed. Avoid contact with eyes or mucous membranes. In case of accidental eye contact, rinse with water.

⚠️ Warnings & Side Effects

Common (≤ 10 %):

• Local Skin Reactions: burning, stinging, itching, mild erythema
• Dryness, peeling of treated area

Less Common (≤ 1 %):

• Folliculitis, acneiform eruptions
• Temporary hypopigmentation

Serious (Rare):

• Secondary Fungal Overgrowth (e.g., Candida spp.) due to altered local flora
• Hypersensitivity Reactions: urticaria, severe contact dermatitis, anaphylaxis (very rare)
• Corticosteroid-related effects (if used beyond recommended duration/area): skin atrophy, striae, telangiectasia, adrenal suppression (especially under occlusion or on large areas)
• Precautions:
  • Avoid prolonged use (> 7 – 10 days) to minimize risk of systemic corticosteroid absorption and resistance emergence.
  • Discontinue if severe irritation or signs of sensitization occur.
  • Use with caution in pediatric populations (< 2 years) and pregnant/lactating women—only under physician recommendation.
  • Do not apply to open wounds, ulcerated lesions, or deep puncture wounds.

🏥 Storage Instructions

Store Flutibact Ointment at 20 °C – 25 °C (68 °F – 77 °F) in its original tube. Protect from direct sunlight and moisture. Close the cap tightly after each use and keep out of reach of children.

🌐 Availability & Purchasing

• United States: No direct branded combination; prescription mupirocin (Bactroban) and topical corticosteroids available separately. Combination compounding is possible in specialized pharmacies under physician order.
• United Kingdom & EU: Combination preparations may be available as branded products; prescription required.
• Australia: Prescription-only; combination topical formulations require dermatologist or specialist‐dermatology consultation.

Individuals may import Flutibact from India under personal importation regulations, provided a valid prescription accompanies the shipment. Customs and local regulations should be reviewed to avoid delays.

🔗 Internal Links to Authoritative Resources

• FDA: Fluticasone Propionate Label
• FDA: Mupirocin Ointment Label
• Drugs.com: Fluticasone Monograph
• Drugs.com: Mupirocin Monograph
• NHS: Impetigo Overview

🔗 Internal Links to Related Dermatology Products (Indian Brands)

• Clindac A Gel – Clindamycin Phosphate 1 % gel for inflammatory acne.
• Adapen Gel – Adapalene 0.1 % gel for comedonal/inflammatory acne.
• Aziderm 10 % Gel – Azelaic Acid 10 % gel for acne & rosacea.

🎥 Educational Video on Combination Therapy for Infected Dermatitis

👨‍⚕️ Expert Insight: Dr. Anjali Verma, Dermatologist

“Combination formulations like Flutibact—fluticasone plus mupirocin—address both inflammation and secondary bacterial infection. This synergistic approach hastens lesion clearance and improves patient comfort, particularly in impetiginized eczema.”

Note: Always consult a healthcare provider before using Flutibact Ointment to ensure proper diagnosis, prescription, and monitoring.