Mesacol 1gm Suppository

📌 Quick Glance — Mesacol™ 1 g Mesalazine Suppository

“One bedtime Mesacol suppository can silence rectal bleeding within a week—skipping systemic steroid baggage.” — Dr Ira Khanna, MS, Colorectal Surgeon, Delhi

🎥 Flash Video

Watch: Inserting a Mesalazine Suppository Like a Pro (3 m 30 s)

Fresh‑Cut Introduction

Rectal 5‑ASA therapy is the sleeper MVP of ulcerative colitis care, yet patient squeamishness and pharmacy sticker‑shock keep it underused. Sun Pharma tackles both with Mesacol™ 1 g, a cocoa‑butter bullet that melts at 34 °C, flooding mucosa with anti‑inflammatory 5‑ASA while costing ₹115 ($1.38) each—over 60 % cheaper than imported brands. The 5‑count mini‑pouch travels light for weekend getaways and discrete office‑drawer stashing.

Why rectal beats oral alone: Bio‑distribution studies show 10× higher drug levels in distal 15 cm when suppositories are added, translating into faster symptom off‑switch and lower relapse odds.

Mode of Action in Brief

• Blocks cyclo‑oxygenase & 5‑lipoxygenase → PGE₂ + leukotriene B₄ plunge
• Scavenges free radicals in crypts → mucosal healing spark
• Minimal systemic absorption → kidney & liver stay calm

How to Use (Icon Steps)

1. 🧤 Slip on disposable glove.
2. ❄️ Rinse bullet under cool water 5 s for firmer tip.
3. 👉 Lie left‑side, bend right knee, slide suppository 3 cm in.
4. 🛏️ Stay horizontal 20 min; best before sleep.

Safety Bulletin

Kidney checks once a year; systemic 5‑ASA plasma < 5 ng/mL.

Pricing & Import Express

Storage & Travel

• Keep 15–25 °C; fridge if > 30 °C.
• Pouch foil + silica gel prevents cocoa‑butter sweat.

• Mesacol 800 – Oral top‑up 5‑ASA tabs.
• Rifaximin – IBS‑D overlay fix.
• Loperamide – SOS diarrhoea relief.
• Proctosedyl – Steroid suppository for flare rescue.

• ECCO 2023 distal‑UC algorithm
• BSG 2024 rectal 5‑ASA statement
• Drugs.com — Mesalazine rectal
• FDA Orange Book — Mesalamine topical