โ Active Ingredient Overview Table:
| ๐ฌ Active Ingredient (Generic Name): | Nicotine |
|---|---|
| ๐ Indication: | Smoking Cessation (Nicotine Replacement Therapy) |
| ๐บ๐ธ US Brand: | Nicorette, Thrive |
| ๐ญ Manufacturer: | Cipla Limited (Founded: 1935) |
| ๐ฆ Packaging: | 9 Chewing Gums per Packet |
| ๐งช Strength: | 4 mg |
| ๐ Delivery Time: | 6โ15 days |
๐ฟ What is Nicotex 4 mg Nicotine Gum?
Nicotex 4 mg offers a higher-dose nicotine replacement therapy (NRT) in chewing gum form, designed to rapidly manage intense cravings and withdrawal symptoms in heavier smokers (20+ cigarettes per day). Unlike combustible tobacco, the gum delivers controlled nicotine doses via buccal mucosa, reducing harmful smoke toxins and smoothing the transition to nicotine independence.
Many smokers face peaks of craving triggered by routine cuesโafter meals, during stress, or upon waking. Nicotex 4 mg gum provides a swift buccal surge of nicotine, alleviating these intense urges within minutes. Clinical studies demonstrate that using 4 mg gum at the first sign of craving, combined with behavioral counseling, doubles the likelihood of successful quitting compared to placebo gum.
Proper chewing techniqueโchew until tingling, then park between cheek and gumโreleases nicotine over 20โ30 minutes, sustaining relief. As cravings diminish, users can taper gum use over 8โ12 weeks, ultimately achieving smoke-free status without long-term dependence on the gum itself.
๐งฌ Pharmacology & Mechanism of Action
| Attribute | Detail |
|---|---|
| Chemical Formula | C10H14N2 |
| Molecular Weight | 162.23 g/mol |
| Bioavailability | ~50โ60% (buccal absorption) |
| Metabolism | Hepatic (CYP2A6) |
| Half-Life | ~2 hours |
Nicotine binds to nicotinic acetylcholine receptors in the brain, releasing dopamine in reward pathways, which reduces withdrawal symptoms and cravings.
๐ก Indications & Dosing Guidelines
| Smoking Category | Dosing |
|---|---|
| Heavy Smokers (>20/day) | 1 gum every 1โ2 hours as needed (max 20 gums/day) |
| Severe Cravings | Up to 2 gums every 1โ2 hours, not to exceed 20 gums/day |
Chew slowly until tingling occurs, park between cheek and gum, and resume chewing when tingle fades. Use for up to 12 weeks. Gradually reduce gum use during weeks 7โ12.
โ ๏ธ Warnings & Side Effects
Common:
- Mouth soreness, hiccups
- Dyspepsia, jaw discomfort
Serious (rare):
- Arrhythmias in cardiovascular patients
- Hypersensitivity reactions
Use caution in patients with temporomandibular joint disease or significant cardiovascular conditions. Educate on chewing technique to minimize side effects.
๐ฅ Storage Instructions
Store Nicotex 4 mg gum at 20โ25ยฐC in a dry place. Keep sealed in foil to maintain freshness. Keep out of reach of children and pets.
๐ Availability & Purchasing
- USA: OTC (Nicorette 4 mg); Ciplaโs Nicotex may require prescription for import.
- UK & EU: OTC availability for generic 4 mg gum.
- Australia: OTC; adhere to TGA guidelines.
Ciplaโs Nicotex 4 mg offers a cost-effective NRT option. Ensure compliance with local health regulations.
๐ Related Nicotine Replacement Products
- Nicotex 2 mg Gum โ for lighter smokers.
- Varenismart 1 mg โ pharmacotherapy alternative.
๐ฅ Educational Video on High-Strength NRT
๐จโโ๏ธ Expert Insight: Dr. Rajeev Mehta, Pulmonologist
โNicotex 4 mg gum is ideal for heavy smokers who require a rapid nicotine surge to control intense cravings. It should be combined with behavioral support for maximum quit success.โ




