Name: Pacroma
SKU: 23400
Availability: InStock

✅ Active Ingredient Overview Table:

🔬 Active Ingredient (Generic Name):	Pimecrolimus 1% w/w
💊 Indication:	Atopic Dermatitis (Mild to Moderate)
🇺🇸 US Brand Equivalent:	Elidel Cream (Pimecrolimus)
🏭 Manufacturer:	Ajanta Pharma Ltd (Founded: 1973)
📦 Packaging:	10 g Tube
🧪 Strength:	1% w/w
🚚 Delivery Time:	6–15 days

🌿 What is Pacroma Cream 1%?

Pacroma Cream contains Pimecrolimus, a topical calcineurin inhibitor indicated for the treatment of mild to moderate atopic dermatitis in patients aged two years and older. Unlike topical corticosteroids, Pimecrolimus selectively inhibits T-cell activation and release of inflammatory cytokines without causing skin atrophy. Pacroma is formulated in a lightweight, non-greasy emulsion that facilitates rapid absorption and improves patient comfort, especially in sensitive areas such as the face and skin folds.

🧬 Pharmacology & Mechanism of Action

Attribute	Detail
Chemical Formula	C41H68N6O10
Molecular Weight	810.03 g/mol
Mechanism	• Calcineurin Inhibition: Binds to macrophilin-12 (FKBP-12) → inhibits calcineurin phosphatase activity → prevents NFAT dephosphorylation → reduces T-cell cytokine (IL-2, IL-4, IL-5) production → decreases skin inflammation.
Absorption	Minimal systemic absorption; <0.5% of applied dose reaches circulation.
Distribution	Predominantly remains localized in the epidermis and dermis where inflammation occurs.
Metabolism	Metabolized by local tissue enzymes; negligible hepatic metabolism.
Half-Life	Not applicable due to minimal systemic bioavailability.

💡 Indications & Application Guidelines

Condition	Application Regimen
Atopic Dermatitis (Age ≥2 years)	• Cleanse and gently pat dry affected area.
• Apply a thin layer of Pacroma Cream to affected skin twice daily (morning & evening).
• Duration: Use until disease control achieved; assess after 6 weeks for continued response.
Sensitive or Facial Dermatitis	• Apply thinly to eczematous areas twice daily.
• Avoid occlusive dressings.

Preparation: Wash hands and affected area with mild soap; pat dry.
Application: Apply a pea-sized amount per small area; spread evenly.
Frequency: Twice daily; if symptoms resolve, continue for an additional 2 days then reassess.
Precautions: Avoid contact with eyes and mucous membranes. Wash hands after application. Not recommended under occlusion.

⚠️ Warnings & Side Effects

Common Side Effects:

Local skin reactions: burning, stinging, pruritus at application site
Mild erythema or warmth

Less Common:

Acneiform eruptions
Folliculitis

Serious (Rare):

Hypersensitivity reactions (rash, urticaria)
Increased risk of cutaneous infections (e.g., viral, fungal) with prolonged use

Precautions:

Infection: Discontinue if secondary skin infection occurs; treat infection prior to resuming.
Sun Exposure: Use sun protection; Pimecrolimus may increase photosensitivity.
Long-term Use: Limit use to affected areas; evaluate periodically.
Malignancy Risk: FDA warns of a potential lymphoma and skin cancer risk; use lowest effective dose and duration.

🏥 Storage Instructions

Store Pacroma Cream at 20°C–25°C. Protect from excessive heat and direct sunlight. Keep tube tightly closed and out of reach of children. Discard 6 months after opening.

🌐 Availability & Purchasing

United States: Available as Elidel Cream by Valeant; prescription required.
United Kingdom & EU: Prescription-only; topical Pimecrolimus available under specialist dermatology guidance.
Australia: PBS-listed; prescription necessary; prescribed by dermatologists for atopic dermatitis.

Importing Pacroma from India:
Importing Pacroma Cream may reduce treatment costs. Ensure you hold a valid prescription and comply with local personal importation regulations to avoid customs delays.

🔗 IAuthoritative Resources

FDA: Pimecrolimus (Elidel) Label & Information

🔗 Related Topical Therapies (Indian Brands)

Betnovate C Cream – Betamethasone + Clioquinol for combined steroid and antimicrobial action by GSK.

🎥 Educational Video on Topical Calcineurin Inhibitors

👩‍⚕️ Expert Insight: Dr. Kavita Rao, Dermatologist

“Topical Pimecrolimus offers a steroid-sparing option for atopic dermatitis, especially in delicate areas where prolonged steroid use risks skin thinning. It effectively targets inflammation with minimal systemic exposure.”