โ Active Ingredient Overview Table:
| ๐ฌ Active Ingredient (Generic Name): | Piroxicam |
|---|---|
| ๐ Indication: | Osteoarthritis, Rheumatoid Arthritis, Ankylosing Spondylitis, Acute Pain |
| ๐บ๐ธ US Brand: | Feldene |
| ๐ญ Manufacturer: | Cipla Limited (Founded: 1935) |
| ๐ฆ Packaging: | 10 Capsules per Strip |
| ๐งช Strength: | 20 mg |
| ๐ Delivery Time: | 6โ15 days |
๐ฟ What is Piroxicam 20 mg (Pirox)?
Pirox delivers 20 mg of Piroxicam, a long-acting nonsteroidal anti-inflammatory drug (NSAID) that non-selectively inhibits COX-1 and COX-2, reducing inflammation, pain, and stiffness in diverse musculoskeletal conditions.
Clinical research demonstrates that once-daily 20 mg dosing maintains effective plasma levels, alleviating joint pain in osteoarthritis and rheumatoid arthritis while providing relief in ankylosing spondylitis and acute gouty episodes.
For detailed prescribing information and safety profiles, refer to the FDA label for Feldene and the Drugs.com monograph. Additional guidance is available via the NHS Medicines AโZ entry and the WHO Essential Medicines List.
๐งฌ Pharmacology & Mechanism of Action
| Attribute | Detail |
|---|---|
| Chemical Formula | C15H13N3O4S |
| Molecular Weight | 331.35 g/mol |
| Bioavailability | ~100% |
| Metabolism | Hepatic (CYP2C9) |
| Half-Life | ~50 hours |
Piroxicamโs long half-life allows steady anti-inflammatory effects with once-daily dosing.
๐ก Indications & Dosing
| Condition | Dose |
|---|---|
| Osteoarthritis & Rheumatoid Arthritis | 20 mg once daily |
| Ankylosing Spondylitis | 20 mg once daily |
| Acute Pain Syndromes | 20 mg once daily (short-term use) |
Administer with food or milk to reduce GI irritation. Do not exceed 20 mg daily.
โ ๏ธ Warnings & Side Effects
Common:
- Gastrointestinal upset (dyspepsia, nausea)
- Headache, dizziness
- Edema
Serious:
- GI bleeding or ulceration
- Cardiovascular events (MI, stroke)
- Renal impairment
Use the lowest effective dose for the shortest possible duration. Monitor renal, hepatic function, and GI symptoms, especially in high-risk patients.
๐ฅ Storage Instructions
Store Pirox 20 mg at 20โ25ยฐC in original packaging. Protect capsules from moisture and light. Keep out of reach of children.
๐ Availability & Purchasing
- USA: Prescription-only (Feldene); limited availability.
- UK & EU: Prescription required; Piroxicam generics available.
- Australia: Prescription and TGA approval required.
Importing from India may offer cost savings; ensure compliance with local regulations and hold a valid prescription.
๐ Related NSAID Options
- Meloxicam 15 mg โ preferential COX-2 inhibitor.
- Naproxen SR 750 mg โ sustained-release NSAID.
- Celecoxib 200 mg โ COX-2 selective inhibitor.
๐ฅ Educational Video on Piroxicam
๐จโโ๏ธ Expert Insight: Dr. Arvind Patel, Rheumatologist
โPiroxicam is ideal for patients needing once-daily NSAID therapy due to its long half-life. However, monitor GI and cardiovascular risks closely.โ





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