🗂️ Quick‑Reference Sheet — Angizem™ 60 mg Tablet

Attribute	Details
Active Ingredient	Diltiazem hydrochloride 60 mg
Drug Class	Benzothiazepine non‑DHP calcium‑channel blocker
Key Uses	Rate control in AF/SVT • Chronic stable & variant angina • Stage‑2 hypertension
Indian Brand	Angizem™ 60 mg
US Reference Brand	Cardizem® 60 mg (Bausch US)
Manufacturer	Sun Pharmaceutical Industries Ltd, Mumbai 🇮🇳 (est. 1983)
Pack Size	15 film‑coated tablets • PVC‑Alu strip
Dispatch ETA	6 – 15 days worldwide ✈️

Angizem™ 60 mg (Diltiazem) — High‑Dose Flex Cardio Guide 2025

“Sixty‑milligram diltiazem hits the sweet spot for both HR control and angina—without needing four pills a day.” — Dr Ananya Ghosh, MD FESC

📺 Video Overview

Watch on YouTube – Diltiazem 60 mg: When & How to Use (4 m 39 s)

Introduction

Doubling the dose, halving the pill count. The 60 mg strength allows BID–TID regimens that maintain therapeutic troughs with fewer daily doses than 30 mg IR tablets. Sun Pharma’s Angizem™ 60 mg leverages the same WHO‑GMP process as the 30 mg version but compresses twice the API for patients escalating therapy. This is especially handy for AF patients aiming for resting HR < 80 bpm or angina patients needing prolonged vasodilation. (See canvas for a 2 800‑word expanded intro on pharmacokinetics, guideline tiering, and cost‑utility.)

Mechanism & Pharmacokinetics

Identical Ca²⁺‑channel blockade profile to 30 mg; Cmax ~184 ng/mL at 60 mg, t½ 3.5 h; hepatic CYP3A4 metabolism.

Evidence Dashboard 2023‑25

Trial	Cohort	Regimen	HR/SBP Δ	Safety
AF‑STEP‑UP 2024	Persistent AF (n = 420)	60 mg TID vs 30 mg QID	HR < 90 bpm in 74 % vs 70 %	Constipation 4 %
ANGINA‑PLUS 2023	Chronic angina (n = 350)	60 mg TID	Exercise +75 s	Fatigue 3 %
HTN‑MODERATE 2025	Stage‑2 HTN Asians (n = 500)	60 mg BID	−14/−9 mmHg	Ankle oedema 1.5 %

Import & Pricing Guide

Region	Rx Class	Landed Price*	Customs Tip
🇺🇸 USA	Rx	$0.19/tab	HS 30049029 ≤90‑day supply
🇬🇧 UK	POM	£0.17/tab	CN22 + Rx; VAT‑free <£39
🇦🇺 AU	S4	A$0.30/tab	TGA personal import
🇪🇺 EU	Rx	€0.17/tab	CE 30049029
*Q2 2025 median, 1 000‑tab lots.

India‑to‑USA Price Ladder (₹→USD @ ₹83)

Strips (15)	FOB Halol	Reg Air	Landed 🇺🇸	Save vs Cardizem®
20	₹270	₹620	$12.10	78 % ↓
100	₹1 200	₹750	$26.30	86 % ↓
500	₹5 300	₹900	$81.40	92 % ↓

Dosing & Clinical Pearls

Rate Control: 60 mg TID (every 8 h) vs 30 mg QID; adjust q3–5 d.
Angina: 60 mg TID – better compliance than 30 mg QID.
Hypertension: 60 mg BID start; uptitrate to SR 120 mg BID if needed.
Combine cautiously with β‑blockers; monitor PR interval.

Safety Highlights

Similar to 30 mg; constipation 4 %, brady < 55 bpm 2 %, AV block 0.4 %, HF decomp 0.3 %. CYP3A4/P‑gp interactions unchanged.

Storage & Travel Tips

Store 15 – 30 °C in the original PVC‑Alu strip; IR diltiazem absorbs moisture and may crumble if left in pill boxes.
Each 15‑tablet strip weighs 1.4 g—ultra‑light for international travel; keep a printed ECG or cardiologist letter to smooth customs checks.
Avoid grapefruit juice and high‑fat meals within 2 h of dosing—both can spike plasma levels by inhibiting intestinal CYP3A4.

Metolar – Metoprolol XL 25 mg alternative rate control.
Telma – Telmisartan 40 mg RAAS blocker; combo with CCB lowers SBP further by 6 mmHg.
Ecosprin – Aspirin 75 mg antiplatelet for CAD patients.
Rivaroxaban – DOAC prevention of AF‑related stroke.