✅ Active Ingredient Overview Table:

🔬 Active Ingredients:	Human Placental Extract (Hydrolyzed), Nitrogen Purged
💊 Indication:	Wound Healing, Tissue Regeneration, Ulcer Management
🇺🇸 US Brand Equivalent:	No exact topical equivalent; related regenerative gels (e.g., Dermaheal HSR)
🏭 Manufacturer:	Albert David Limited (Founded: 1955)
📦 Packaging:	20 g Tube
🧪 Strength:	1000 IU of placental extract equivalent per gram, Nitrogen atmosphere enriched
🚚 Delivery Time:	6–15 days

🌿 What is Placentrex Gel?

Placentrex Gel harnesses hydrolyzed human placental extract, rich in growth factors, cytokines, and amino acids, to promote accelerated wound healing and tissue regeneration. The nitrogen-enriched formulation ensures preservative-free stability and enhanced bioavailability of active proteins. Placentrex Gel is indicated for chronic wounds, burns, diabetic foot ulcers, bedsores, and other non-healing ulcers. By stimulating fibroblast proliferation, collagen synthesis, and neovascularization, it supports the formation of healthy granulation tissue and reduces scar formation.

🧬 Pharmacology & Mechanism of Action

Component	Mechanism
Human Placental Extract	• Contains growth factors (EGF, FGF, PDGF) → stimulates keratinocyte and fibroblast proliferation → enhances epithelialization.
• Rich in amino acids and nucleotides → supports collagen synthesis and matrix remodeling.
• Contains anti-inflammatory cytokines → reduces local inflammation and oxidative stress.
Nitrogen Atmosphere	• Creates an oxygen-free environment → prevents protein denaturation and microbial contamination without chemical preservatives.
Gel Base (Hydrogel Matrix)	• Provides moist wound environment → promotes autolytic debridement, pain reduction, and patient comfort.
• Ensures uniform application and controlled release of active constituents.

💡 Indications & Application Guidelines

Condition	Application Regimen
Chronic Non-Healing Wounds & Ulcers	• Cleanse wound with sterile saline; pat dry sterile gauze.
• Apply a thin layer of Placentrex Gel to wound bed once daily under sterile conditions.
• Cover with sterile dressing; change daily or per exudate level.
• Duration: Continue until complete epithelialization (usually 2–6 weeks).
Diabetic Foot Ulcers	• Debride necrotic tissue if present; cleanse with antiseptic as per protocol.
• Apply Placentrex Gel daily; cover with sterile, non-adherent dressing.
• Advise offloading techniques and glycemic control.
• Duration: Use until ulcer closure; adjunct to standard diabetic foot care.
Burn Wounds (Superficial Partial-Thickness)	• Cool burn area with saline; remove loose debris.
• Apply Placentrex Gel sparingly to burn once or twice daily.
• Cover with non-stick sterile dressing; change every 24 hours.
• Duration: Continue until re-epithelialization (approximately 1–3 weeks).

Preparation: Always perform wound cleaning and debridement prior to application.
Sterility: Use sterile gloves and instruments; avoid contamination.
Frequency: Once daily application is sufficient; adjust to twice daily in high-exudate wounds.
Precautions: Avoid gel contact with intact skin; apply only to wound bed and margins.
Pediatric & Geriatric Use: Use under specialist supervision; monitor for allergic reactions.

⚠️ Warnings & Side Effects

Common (Local):

Mild transient burning or stinging on application
Temporary erythema or mild irritation

Less Common:

Contact dermatitis or allergic reaction (rash, pruritus)
Maceration of peri-wound skin if exudate is high and dressing not changed timely

Precautions:

Hypersensitivity: Contraindicated in patients with known allergy to placental proteins or gel excipients.
Infection: Do not use on heavily infected wounds without systemic antibiotic coverage.
Systemic Effects: Minimal risk due to topical application; monitor for local reactions.
Pregnancy & Lactation: Use only if clearly needed; no systemic absorption expected but caution in lactating patients.
Combination Therapy: Can be used concomitantly with standard wound care (e.g., debridement, antimicrobial dressings).

🩺 Storage Instructions

Store Placentrex Gel at 2–8°C (refrigerate) in original tube. Protect from direct sunlight and freezing. Once opened, use within 30 days. Keep cap tightly closed. Discard if gel color changes or odor develops. Keep out of reach of children.

🌐 Availability & Purchasing

United States: Prescription-only; no direct equivalent; compounding pharmacies may offer regenerative gels.
United Kingdom & EU: Prescription required; regenerative and growth factor gels available under specialist supervision.
Australia: TGA approval required; prescription needed; import permitted with valid prescription.

Importing from India:
Purchasing Placentrex Gel from India offers cost benefits. Ensure compliance with local import regulations, maintain a valid prescription, and verify product authenticity to avoid counterfeit products.

🔗 Authoritative Resources

🔗 Related Topical Therapies (Indian Brands)

Fucidin Gel – Fusidic Acid 2% for infected wounds by Leo Pharma.

🎥 Educational Video on Regenerative Wound Therapy

👨‍⚕️ Expert Insight: Dr. Rohan Gupta, Wound Care Specialist

“Placentrex Gel’s growth factor–rich profile accelerates granulation and epithelialization in non-healing wounds. Maintaining a moist environment and preventing peri-wound maceration are key to optimizing outcomes.”