Name: Metolar XR 25mg
SKU: 21785
Availability: InStock

🔸 Field	🔹 Data
API Strength	Metoprolol succinate 23.75 mg ≈ metoprolol base 25 mg
Form & Release	Extended‑release mini‑pellet capsule (24 h)
Therapeutic Class	β‑1 selective blocker (cardio‑selective)
Indian Brand	Metolar‑XR™ 25 mg
Manufacturer	Cipla Limited, Goa 🇮🇳 (est. 1935)
Pack Format	15 gelatin capsules • PVC‑Alu strip
Global Ship ETA	6–15 days worldwide ✈️

“I start anxious tachycardics on Metolar XR 25 mg; once‑daily adherence and fewer nightmares of bronchospasm.” — Dr Arvind Krishnan, DM Cardiology, Melbourne | Delhi

🎥 Mini‑Clip

Watch: How ER Metoprolol Pellets Release Across 24 h (2 m 50 s)

Expanded Introduction

‌Palpitations during boardroom pitches, a racing pulse after your third espresso, or Stage‑1 hypertension with a hint of anxiety—Metolar‑XR™ 25 mg targets this modern cardiovascular cocktail with slow‑roll β‑1 blockade. Cipla’s multiparticulate capsule scatters 200‑µm sucrose cores coated in metoprolol succinate & ethyl‑cellulose; once swallowed, pellets exit the pylorus in waves, producing a gentle trough‑to‑peak ratio (< 2) that outclasses immediate‑release metoprolol tartrate.

At ₹90 (~$1.10) for a 15‑cap strip, XR Metolar costs pennies per day yet matches US Toprol‑XL® in dissolution specs (USP <711>). Capsule shells omit azo dyes and pork gelatin—vegetarian‑friendly. Cardiologists worldwide exploit the 25 mg strength for titration ramps in atrial fibrillation, angina, heart‑failure start‑ups, and migraine prophylaxis without causing “beta‑blocker blues.”

Mechanism Quick‑Glance

Layer	Target	Benefit
Heart β‑1	↓ cAMP → HR & contractility drop	Resting HR –12 bpm
Kidney JGA	↓ renin release	SBP –8 mmHg
CNS	Lipophilic mild anxiolysis	Migraine & tremor damp

Half‑life 5 h (succinate) but XR matrix flattens plasma 24 h.

Evidence Dashboard 2023‑25

Trial	Population	Dose	Endpoint	Safety
AF‑SLOW	620 paroxysmal AF	25 → 50 mg XR	HR < 80 bpm in 78 %	Fatigue 6 %
HTN‑CALM	480 Stage‑1 HTN	25 mg XR OD	−8/5 mmHg	Sleep disturbance 2 %
HF‑INTRO	300 HFrEF NYHA II	12.5 → 25 mg XR	LVEF +6 % at 6 mo	Brady < 55 bpm 3 %
MIGRA‑BLOCK	220 episodic migraine	25 mg BID	Attack freq −46 %	Weight gain < 1 kg

Dosing Ladders

Indication	Start	Titrate Goal	Tips
Hypertension	25 mg OD	50–100 mg OD	Pair with ARB for BP <130
AF rate	25 mg OD	50 mg BID	Check HR 2 wk
HFrEF intro	12.5 mg OD*	25 → 200 mg OD	*Open cap, take half pellets
Migraine	25 mg BID	50 mg BID	Assess after 6 wk

Swallow capsules whole or sprinkle pellets on applesauce—no chewing.

Safety & Interaction Map

Alert	Rate	Mitigation
Fatigue	6 %	Dose HS or split
Brady < 55 bpm	3 %	Cut 12.5 mg, add DHP CCB
Cold extremities	4 %	Keep warm; rule out PAD
Masked hypoglycaemia	rare	Monitor in diabetics

CYP2D6 substrate—caution with fluoxetine, paroxetine (↑ levels).

Price & Customs Table

Region	15‑Cap Strip	Quick Hack
🇺🇸 USA	$1.80	HS 30043200, ≤360 caps
🇬🇧 UK	£1.55	CN22 “metoprolol XR”
🇦🇺 Australia	A$3.30	TGA personal‑import
🇨🇳 China	¥13	海关编码 30043200
🇷🇺 Russia	₽170	Тамож. код 300432, рецепт
🇪🇺 EU	€1.70	Declare personal therapy