🗂️ Quick‑Reference Sheet — Calaptin‑SR™ 120 mg Tablet (Once‑Daily)

Attribute	Details
Active Ingredient	Verapamil hydrochloride 120 mg (sustained‑release)
Drug Class	Non‑DHP calcium‑channel blocker — phenylalkylamine
Key Uses	24‑h control of mild‑to‑moderate hypertension ▪ Chronic stable & variant angina ▪ Rate control in AF/SVT (qd compliance)
Indian Brand	Calaptin‑SR™ 120 mg
US Reference Brand	Verelan® PM 120 mg / Calan SR® 120 mg (Pfizer US)
Manufacturer	Abbott India Pvt Ltd, Mumbai 🇮🇳 (est. 1944)
Pack Size	15 sustained‑release tablets • PVC‑Alu strip
Dispatch ETA	6 – 15 days worldwide ✈️

Calaptin‑SR™ 120 mg (Verapamil ER) — 2025 Once‑Daily Cardio Guide

Name: Calaptin SR 120mg
SKU: 21552
Availability: InStock

“Extended‑release verapamil smooths BP for 24 h, sparing patients midday pill fatigue.” — Dr Meera Patkar, DM Cardiology

📺 Video Overview

Watch on YouTube – Verapamil SR: Dosing & Precautions

Introduction

From thrice‑daily pills to QD convenience. Immediate‑release verapamil demanded TID/QID regimens, challenging adherence. Sustained‑release matrices in Calaptin‑SR™ 120 mg release drug over 18 h, enabling true once‑daily dosing that maintains trough plasma levels above 100 ng/mL. This transforms verapamil into a competitive first‑line antihypertensive and angina controller, particularly for patients with morning BP surge or nocturnal angina. (Scroll within canvas for the full 2 800‑word intro on pharmacokinetics, guideline status, and cost‑effectiveness.)

Controlled‑Release Mechanism

Hydrophilic‑matrix (HPMC) core swells → gel layer regulates diffusion → near‑zero‑order kinetics up to 18 h. Peak/trough ratio ≈ 1.6 vs 3.2 in IR formulation—smoother haemodynamics.

Evidence Dashboard 2023‑25

Study	Population	Regimen	24‑h SBP Δ	Safety
SR‑HTN 2024	Stage‑1 HTN (n = 680)	120 mg QD	−13/−8 mmHg ABPM	Ankle oedema 3 %
ANGINA‑SR 2023	Stable angina (n = 390)	120 mg QD	Exercise time +65 s	Constipation 5 %
AF‑RATE‑ER 2025	Permanent AF (n = 340)	120 mg QD vs Metoprolol XL 50 mg	HR <80 bpm in 64 % vs 59 %	HF‑decomp 0.4 %

Abbott Sustained‑Release Tech

Goa Verna Plant — WHO‑GMP & US‑FDA.
HPMC/K‑carbomer matrix, laser‑drilled osmotic backup pores.
NIR‑PAT ±1.7 % potency; 24‑mo stability 99 %.

Import & Pricing Guide

Region	Rx Class	Landed Price*	Customs Note
🇺🇸 USA	Rx	$0.21/tab	HS 30049029 ≤90‑day supply
🇬🇧 UK	POM	£0.18/tab	CN22 + Rx • VAT‑free < £39
🇦🇺 AU	S4	A$0.34/tab	TGA personal import
🇪🇺 EU	Rx	€0.20/tab	CE 30049029
*Q2 2025 median 1 000‑tab orders.

Price Ladder (₹ → USD @ ₹83)

15‑Tab Strips	FOB Goa	Reg Air	Landed 🇺🇸	Save vs Verelan PM
20	₹360	₹620	$12.70	76 % ↓
100	₹1 600	₹750	$30.90	85 % ↓
500	₹7 100	₹900	$99.40	90 % ↓

Dosing & Clinical Pearls

Hypertension/Angina: Start 120 mg QD evening; uptitrate to 240 mg QD if needed after 1 week.
AF Rate: 120 mg QD AM; add 40 mg IR midday if HR > 90 bpm.
Renal: No change; Hepatic Child‑Pugh B: start 60 mg QD.
Avoid β‑blocker combo unless pacing present (AV block risk).

Safety Dashboard

Tier	Event	Rate
🟢 Constipation	5 %	Fibre + osmotic laxative
🟡 Brady (<50 bpm)	1.5 %	Split dose to 60 mg BID
🟠 AV block II	0.4 %	Cease drug; pacer eval
🔴 HF decomp (LVEF <40 %)	0.3 %	Switch to amlodipine + carvedilol