Name: Betnovate GM
SKU: 23221
Availability: InStock

✅ Active Ingredient Overview Table:

🔬 Active Ingredients:	Betamethasone Valerate 0.1% w/w, Gentamicin Sulfate 0.1% w/w, Miconazole Nitrate 2% w/w
💊 Indication:	Inflamed Dermatoses with Secondary Bacterial/Fungal Infection
🇺🇸 US Brand Equivalent:	Comparable standalone components: Diprolene (Betamethasone), Gentak (Gentamicin), Monistat (Miconazole)
🏭 Manufacturer:	GlaxoSmithKline Pharmaceuticals Ltd (Founded: 2000)
📦 Packaging:	20 g Ointment Tube
🚚 Delivery Time:	6–15 days

🌿 What Is Betnovate GM Ointment?

Betnovate GM Ointment merges a potent topical corticosteroid (Betamethasone Valerate 0.1%) with an aminoglycoside antibiotic (Gentamicin Sulfate 0.1%) and an imidazole antifungal (Miconazole Nitrate 2%). This tri‐action formulation is indicated for inflammatory skin disorders complicated by mixed bacterial and fungal infections—such as tinea‐associated eczemas, interdigital fungal intertrigo with secondary bacterial overgrowth, and impetiginized psoriasis. Betamethasone reduces inflammation and itching, gentamicin eradicates susceptible Gram‐negative and some Gram‐positive bacteria, and miconazole targets dermatophytes and Candida species, facilitating rapid lesion clearance and symptom relief.

🧬 Pharmacology & Mechanism of Action

Component	Mechanism
Betamethasone Valerate 0.1%	• Binds glucocorticoid receptors → downregulates inflammatory cytokines (IL‑1, TNF‑α) • Inhibits leukocyte migration → reduces erythema, edema, and pruritus
Gentamicin Sulfate 0.1%	• Binds 30S ribosomal subunit → inhibits protein synthesis → bactericidal against Pseudomonas, E. coli, Staph. spp.
Miconazole Nitrate 2%	• Inhibits lanosterol 14α-demethylase → disrupts ergosterol synthesis → fungistatic/fungicidal against dermatophytes and yeasts (Candida)
Ointment Base	• Semi-occlusive emollient vehicle → enhances penetration of active ingredients and maintains moist environment for healing

💡 Indications & Application Guidelines

Condition	Application Regimen
Tinea‐Associated Eczema (Dermatophyte plus Bacterial Overgrowth)	• Cleanse and pat dry affected area. • Apply a thin layer of Betnovate GM Ointment 2× daily (morning and evening) for 7–10 days. • Discontinue gentamicin and miconazole components after 7–10 days; continue betamethasone alone if inflammation persists (max 14 days total).
Intertrigo with Secondary Infection (Bacterial and Candida)	• Gently cleanse; apply Betnovate GM Ointment to affected sites twice daily for 5–7 days. • If fungal elements persist, switch to miconazole mono‐therapy after initial combination phase.
Impetiginized Psoriatic Lesions with Fungal Colonization	• Clean and dry plaques; apply thin layer twice daily for 7 days. • After bacterial/fungal resolution, continue betamethasone for inflammation control (max 14 days total).

Preparation: Wash hands and lesion with mild soap; pat dry.
Application: Dispense a pearl‐sized amount onto fingertip; spread evenly to cover entire lesion and margin.
Frequency: Twice daily—morning and evening. Adjust based on tolerance; if irritation occurs, reduce to once daily.
Duration: Combination therapy limited to 7–10 days; steroid component may continue up to 14 days under supervision.

Avoid occlusive dressings unless prescribed. Discontinue if severe irritation, hypersensitivity, or worsening infection occurs. Do not apply to mucous membranes, open deep wounds, or ophthalmic regions.

⚠️ Warnings & Side Effects

Common:

Burning or stinging upon application
Erythema, dryness, peeling
Folliculitis

Less Common:

Contact dermatitis (allergic)
Hypopigmentation
Local candidal overgrowth if used beyond recommended duration

Serious (Rare):

Skin atrophy, striae, telangiectasia (with prolonged steroid use)
HPA axis suppression (especially under occlusion or on large areas)
Nephrotoxicity or ototoxicity (rare systemic absorption of gentamicin if applied to extensive areas)

Precautions:

Limit gentamicin use to ≤10 days to reduce resistance risk and nephrotoxicity; monitor for signs of ototoxicity (tinnitus, hearing loss) if applied extensively.
Restrict betamethasone to ≤14 days to prevent skin atrophy and systemic effects.
Use miconazole for ≤10 days; extended use may cause local irritation or promote resistant fungal strains.
Avoid use in children <2 years without pediatric dermatologist oversight.
Discontinue if hypersensitivity reactions (rash, swelling, severe pruritus) occur.

Inform patients to notify if signs of systemic toxicity (e.g., dizziness, auditory changes) or persistent infection appear.

🏥 Storage Instructions

Store Betnovate GM Ointment at 20–25°C (68–77°F) in its original tube. Protect from direct sunlight and moisture. Ensure cap is tightly closed after each use. Discard 6 months after opening. Keep out of reach of children and pets.

🌐 Availability & Purchasing

United States: No direct combination product; components (Betamethasone, Gentamicin, Miconazole) available separately by prescription. Combination compounding feasible in specialized pharmacies under physician order.
United Kingdom & EU: Prescription required; combination topical steroid/antibiotic/antifungal products are prescription‐only. Dermatologists commonly prescribe similar triple‐action ointments.
Australia: Prescription mandatory; triple‐agent topical formulations available by dermatologist prescription.

Importing Betnovate GM from India may offer cost advantages. Ensure compliance with local importation and customs regulations; maintain valid prescription documentation to prevent delays.

🔗 Authoritative Resources

🔗 Related Topical Combination Therapies (Indian Brands)

Betnovate C Ointment – Betamethasone + Clioquinol for infected dermatoses.
Betnovate N Ointment – Betamethasone + Neomycin for bacterial dermatitis.
Betnovate S Ointment – Betamethasone + Salicylic Acid for hyperkeratotic lesions.
Betnovate GM Ointment – Betamethasone + Gentamicin + Miconazole for mixed infections.

🎥 Educational Video on Triple‐Action Topical Therapy

Understand how Betnovate GM’s combination approach accelerates healing in mixed infections:

👩‍⚕️ Expert Insight: Dr. Sangeeta Patel, Dermatologist

“Betnovate GM’s inclusion of gentamicin and miconazole alongside a potent corticosteroid offers comprehensive coverage for mixed fungal and bacterial infections on an inflamed base. It’s crucial to limit duration to avoid resistance and minimize systemic absorption.”